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Peroksidni antimalarici

dc.creatorOpsenica, Dejan M.
dc.creatorŠolaja, Bogdan A.
dc.date.accessioned2018-11-22T00:15:28Z
dc.date.available2018-11-22T00:15:28Z
dc.date.issued2009
dc.identifier.issn0352-5139
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1033
dc.description.abstractThe problem of endemic malaria continues unabated globally. Malaria affects 40 % of the global population, causing an estimated annual mortality of 1.5-2.7 million people. The World Health Organization (WHO) estimates that 90 % of these deaths occur in sub-Saharan Africa among infants under the age of five. While a vaccine against malaria continues to be elusive, chemotherapy remains the most viable alternative towards treatment of the disease. During last years, the situation has become urgent in many ways, but mainly because of the development of chloroquine-resistant (CQR) strains of Plasmodium falciparum (Pf). The discovery that artemisinin (ART, 1), an active principle of Artemisia annua L., expresses a significant antimalarial activity, especially against CQR strains, opened new approaches for combating malaria. Since the early 1980s, hundreds of semi-synthetic and synthetic peroxides have been developed and tested for their antimalarial activity, the results of which were extensively reviewed. In addition, in therapeutic practice, there is no reported case of drug resistance to these antimalarial peroxides. This review summarizes recent achievements in the area of peroxide drug development for malaria chemotherapy.en
dc.description.abstractŠirenje malarije je stalno prisutan problem na globalnom nivou. Od malarije godišnje oboli 40 % svetske populacije i oko 1,5-2,7 miliona ljudi umre. Prema podacima Svetske zdravstvene organizacije, 90 % smrtnih slučajeva je u zemljama podsaharske Afrike, među kojima dominiraju deca starosti do 5 godina. Usled nemogućnosti razvoja vakcine, hemoterapija ostaje kao jedini pouzdan oblik lečenja od ove bolesti. Poslednjih godina problem borbe protiv malarije postaje urgentan iz brojnih razloga, među kojima je najznačajniji razvoj hlorokin-rezistentnih sojeva parazita. Otkriće da artemizinin (ART, 1) i njegovi derivati pokazuju izuzetnu efikasnost prema hlorokin-rezistentnim sojevima otvorilo je velike mogućnosti u borbi protiv malarije. Od tada, posebno tokom 80-tih godina, sintetisan je veliki broj jedinjenja i rezultati njihove aktivnosti opisani su u mnogim naučnim publikacijama. Osim toga, u kliničkoj praksi nisu zabeleženi primeri pojave rezistencije parazita prema ovoj klasi antimalarika. U ovom revijalnom radu opisani su najnoviji rezultati u razvoju peroksidnih antimalarika.sr
dc.publisherSerbian Chemical Soc, Belgrade
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectantimalarialen
dc.subjectperoxidesen
dc.subjectperoxidesen
dc.subjecttrioxanesen
dc.subjecttrioxanesen
dc.subjecttrioxolanesen
dc.subjecttrioxolanesen
dc.subjecttetraoxanesen
dc.subjecttetraoxanesen
dc.subjectchimerasen
dc.subjectchimerasen
dc.titleAntimalarial peroxidesen
dc.titlePeroksidni antimalaricisr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractОпсеница, Дејан М.; Шолаја, Богдан A.; Пероксидни антималарици; Пероксидни антималарици;
dc.citation.volume74
dc.citation.issue11
dc.citation.spage1155
dc.citation.epage1193
dc.identifier.wos000272469700001
dc.identifier.doi10.2298/JSC0911155O
dc.citation.other74(11): 1155-1193
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.rcubKon_2033


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