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dc.creatorFilipovic, Dragana
dc.creatorMandić, Ljuba M.
dc.creatorKanazir, Dusan
dc.creatorPajovic, Snezana B.
dc.date.accessioned2018-11-22T00:16:16Z
dc.date.available2018-11-22T00:16:16Z
dc.date.issued2010
dc.identifier.issn0300-8177
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1072
dc.description.abstractCellular protection against oxidative stress is afforded by the enzyme superoxide dismutase (SOD). In this study, the protein levels of copper-zinc SOD (CuZnSOD) in the cytosolic and nuclear fraction, manganese SOD (MnSOD) in the mitochondrial, and cytosolic fraction and cytochrome c (cyt c) in the liver of male rats exposed to 2 h of acute immobilization (IM) or Cold stress, 21 days chronic isolation or their combinations (chronic/acute stress) were examined. The serum corticosterone (CORT) level was measured, as an indicator of stress stimuli. Both acute stressors with elevated CORT levels caused a decrease of mitochondrial MnSOD, while acute IM resulted in redistribution of the CuZnSOD protein level between the cytosolic and nuclear fraction. Chronic isolation, during which the CORT level was close to control value, resulted in an increase of cytosolic CuZnSOD, whereas a decrease of MnSOD in mitochondrial and its corresponding increase in cytosol fraction was found. In both combined stress regimes, an increase of the CuZnSOD and MnSOD levels in the cytosolic fraction was recorded whereby increase of the CORT level was observed only in the chronic isolation followed by acute IM. The data indicate that acute and/or chronic stress models have different degrees of influence on serum CORT and SOD subcellular protein levels. Increased cytosolic CuZnSOD protein level under chronic isolation suggests that state of oxidative stress may also exist under CORT level similar to the basal value. The presence of MnSOD and cyt c in the cytosolic fraction could serve as useful parameters for mitochondrial dysfunction.en
dc.publisherSpringer, Dordrecht
dc.rightsrestrictedAccess
dc.sourceMolecular and Cellular Biochemistry
dc.subjectCuZnSODen
dc.subjectCorticosteroneen
dc.subjectCytochrome cen
dc.subjectLiveren
dc.subjectMnSODen
dc.subjectStressen
dc.titleAcute and/or chronic stress models modulate CuZnSOD and MnSOD protein expression in rat liveren
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМандић, Љуба М.; Филиповиц, Драгана; Пајовиц, Снезана Б.; Каназир, Дусан;
dc.citation.volume338
dc.citation.issue1-2
dc.citation.spage167
dc.citation.epage174
dc.identifier.wos000276745400018
dc.identifier.doi10.1007/s11010-009-0350-8
dc.citation.other338(1-2): 167-174
dc.citation.rankM23
dc.identifier.pmid20020182
dc.identifier.rcubKon_2072


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