Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative
2010
Authors
Alexandru, Maria-GabrielaĆirković-Veličković, Tanja
Jitaru, Ioana
Grgurić-Šipka, Sanja
Draghici, Constantin
Article (Published version)
Metadata
Show full item recordAbstract
This paper presents the synthesis of complex compounds of type [M(L1)(2)], where M(II) = Cu (1), Co (2), Zn (3), L1 = 2-aminothiazole-4-acetate and [Mn(L1)(2)(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)(2)(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control.
Keywords:
Aminothiazole / Cytotoxicity / HeLa / PBMCSource:
Central European Journal of Chemistry, 2010, 8, 3, 639-645Publisher:
- De Gruyter Poland Sp Zoo, Warsaw
Funding / projects:
- Ispitivanje strukture i funkcije biološki važnih makromolekula u fiziološkim i patološkim stanjima (RS-MESTD-MPN2006-2010-142020)
DOI: 10.2478/s11532-010-0022-2
ISSN: 1895-1066
WoS: 000277021300022
Scopus: 2-s2.0-77951908042
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Alexandru, Maria-Gabriela AU - Ćirković-Veličković, Tanja AU - Jitaru, Ioana AU - Grgurić-Šipka, Sanja AU - Draghici, Constantin PY - 2010 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1075 AB - This paper presents the synthesis of complex compounds of type [M(L1)(2)], where M(II) = Cu (1), Co (2), Zn (3), L1 = 2-aminothiazole-4-acetate and [Mn(L1)(2)(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)(2)(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control. PB - De Gruyter Poland Sp Zoo, Warsaw T2 - Central European Journal of Chemistry T1 - Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative VL - 8 IS - 3 SP - 639 EP - 645 DO - 10.2478/s11532-010-0022-2 ER -
@article{ author = "Alexandru, Maria-Gabriela and Ćirković-Veličković, Tanja and Jitaru, Ioana and Grgurić-Šipka, Sanja and Draghici, Constantin", year = "2010", abstract = "This paper presents the synthesis of complex compounds of type [M(L1)(2)], where M(II) = Cu (1), Co (2), Zn (3), L1 = 2-aminothiazole-4-acetate and [Mn(L1)(2)(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)(2)(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control.", publisher = "De Gruyter Poland Sp Zoo, Warsaw", journal = "Central European Journal of Chemistry", title = "Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative", volume = "8", number = "3", pages = "639-645", doi = "10.2478/s11532-010-0022-2" }
Alexandru, M., Ćirković-Veličković, T., Jitaru, I., Grgurić-Šipka, S.,& Draghici, C.. (2010). Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative. in Central European Journal of Chemistry De Gruyter Poland Sp Zoo, Warsaw., 8(3), 639-645. https://doi.org/10.2478/s11532-010-0022-2
Alexandru M, Ćirković-Veličković T, Jitaru I, Grgurić-Šipka S, Draghici C. Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative. in Central European Journal of Chemistry. 2010;8(3):639-645. doi:10.2478/s11532-010-0022-2 .
Alexandru, Maria-Gabriela, Ćirković-Veličković, Tanja, Jitaru, Ioana, Grgurić-Šipka, Sanja, Draghici, Constantin, "Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative" in Central European Journal of Chemistry, 8, no. 3 (2010):639-645, https://doi.org/10.2478/s11532-010-0022-2 . .