Show simple item record

Rendgenska strukturna analiza i citotoksična aktivnost pikolinato rutenijum(II)-arenskog kompleksa

dc.creatorIvanovic, Ivanka
dc.creatorGrgurić-Šipka, Sanja
dc.creatorGligorijević, Nevenka
dc.creatorRadulović, Siniša S.
dc.creatorRoller, Alexander
dc.creatorTešić, Živoslav Lj.
dc.creatorKeppler, Bernhard K.
dc.date.accessioned2018-11-22T00:18:01Z
dc.date.available2018-11-22T00:18:01Z
dc.date.issued2011
dc.identifier.issn0352-5139
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1149
dc.description.abstractA ruthenium(II)-arene complex with picolinic acid, [(eta(6)-p-cymene)RuCl(pico)]center dot H(2)O, was prepared by the reaction of [(eta(6)-p-cymene)RuCl(2)](2) with picolinic acid in a 1:2 molar ratio in 2-propanol. The compound was characterized by elemental analysis, and IR and NMR spectroscopy. X-ray diffraction analysis showed that the molecule adopts a "three-leg piano-stool" geometry, which is common for this type of complexes. The cytotoxic activity of the complex was tested in two human cancer cell lines HeLa (cervix) and FemX (melanoma) by MTT assay. The IC(50) values were at 82.0 and 36.2 mu mol dm(-3) for HeLa and FemX cells, respectively.en
dc.description.abstractRutenijum(II)-arenski kompleks sa pikolinskom kiselinom [(η6-p-cimen)RuCl(pikolinato)]·H2O sintetisan je u reakciji [(η6-p-cimen)RuCl2]2 kompleksa sa pikolinskom kiselinom u molskom odnosu 1:2 u izopropanolu. Jedinjenje je okarakterisano elementalnom analizom, IC i NMR spektroskopijom. Analiza difrakcijom X-zracima pokazala je da molekul ima tzv. 'three-leg piano-stool' geometriju koja je karakteristična za ovaj tip kompleksa. Citotoksična aktivnost kompleksa je određena na dve humane tumorske ćelijske linije, HeLa (grlića materice) i FemX (melanoma), MTT testom. IC50 vrednosti su bile 82,0 i 36,2 µmol dm-3 za HeLa i FemX ćelije, redom.sr
dc.publisherSerbian Chemical Soc, Belgrade
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142062/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145035/RS//
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectruthenium(II)-areneen
dc.subjectpicolinic aciden
dc.subjectpicolinic aciden
dc.subjectcytotoxic activityen
dc.subjectcytotoxic activityen
dc.titleX-Ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complexen
dc.titleRendgenska strukturna analiza i citotoksična aktivnost pikolinato rutenijum(II)-arenskog kompleksasr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractРоллер, Aлеxандер; Радуловиц, Синиса; Кепплер, Бернхард К.; Глигоријевиц, Невенка; Тешић, Живослав Љ.; Гргурић-Шипка, Сања; Ивановиц, Иванка; Рендгенска структурна анализа и цитотоксична активност пиколинато рутенијум(ИИ)-аренског комплекса; Рендгенска структурна анализа и цитотоксична активност пиколинато рутенијум(ИИ)-аренског комплекса;
dc.citation.volume76
dc.citation.issue1
dc.citation.spage53
dc.citation.epage61
dc.identifier.wos000287060100007
dc.identifier.doi10.2298/JSC100517017I
dc.citation.other76(1): 53-61
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-79951661276
dc.identifier.rcubKon_2149


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record