Isolation and Biological Evaluation of Jatrophane Diterpenoids from Euphorbia dendroides
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Milosavljević, Slobodan M.
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From the Montenegrin spurge Euphorbia dendroides, seven new diterpenoids [jatrophanes (1-6) and a tigliane (7)] were isolated and their structures elucidated by spectroscopic techniques. The biological activity of the new compounds was studied against four human cancer cell lines. The most effective jatrophane-type compound (2) and its structurally closely related derivative (1) were evaluated for their interactions with paclitaxel and doxorubicin using a multidrug-resistant cancer cell line. Both compounds exerted a strong reversal potential resulting from inhibition of P-glycoprotein transport.
Source:Journal of Natural Products, 2011, 74, 7, 1613-1620
- Amer Chemical Soc, Washington