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dc.creatorKrstic, Milena
dc.creatorSovilj, Sofija P.
dc.creatorGrgurić-Šipka, Sanja
dc.creatorEvans, Ivana Radosavljevic
dc.creatorBorozan, Suncica
dc.creatorSantibanez, Juan Francisco
dc.date.accessioned2018-11-22T00:18:50Z
dc.date.available2018-11-22T00:18:50Z
dc.date.issued2011
dc.identifier.issn0223-5234
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1201
dc.description.abstractThree new ruthenium(II) complexes 1-3 containing N-alkylphenothiazine molecules were synthesized by reaction of [RuCl2(eta(6)-P-cymene)](2) with chlorpromazine hydrochloride (1), trifluoperazine dihydrochloride (2) or thioridazine hydrochloride (3). The compounds of the general formula L[RuCl3(eta(6)-p-cymene)] were characterized by elemental analysis and spectroscopic methods (FT-IR, UV-Vis, H-1 and C-13 NMR). Complex 2 was structurally characterized by single crystal X-ray diffraction. In vitro cytotoxic activity of complexes 1-3 were assayed in four human carcinoma cell lines MCF-7, MDA-MB-453 (breast carcinoma), SW-480 (colon carcinoma) and IM9 (myeloma multiple cells). The highest cytotoxicity (12.1 lt = IC50 lt = 17.3 mu M) and induced a total (SW-480) or almost total cell death (MCF-7. MDA-MB-453) at 25 mu M in 48 h of treatment were observed for complex 2. The influence of three different doses (0.4, 4.5 and 90.4 mu M/kg bw) of complex 2 on activities of antioxidants enzymes (superoxide dismutase (SOD) and catalase (CAT)) and lactate dehydrogenase (LDH) were investigated under physiological conditions. The effects on nitrite production (NO2-) and level of erythrocytes malondialdehyde (MDA) in rats blood were evaluated, too. (C) 2011 Elsevier Masson SAS. All rights reserved.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Paris
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172014/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectRuthenium complexesen
dc.subjectp-Cymeneen
dc.subjectN-Alkylphenothiazinesen
dc.subjectSingle crystal X-ray diffractionen
dc.subjectCytotoxicityen
dc.subjectAntioxidant enzymesen
dc.titleSynthesis, structural and spectroscopic characterization, in vitro cytotoxicity and in vivo activity as free radical scavengers of chlorido(p-cymene) complexes of ruthenium(II) containing N-alkylphenothiazinesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБорозан, Сунцица; Еванс, Ивана Радосављевиц; Гргурић-Шипка, Сања; Сантибанез, Јуан Францисцо; Крстиц, Милена; Совиљ, Софија П.;
dc.citation.volume46
dc.citation.issue9
dc.citation.spage4168
dc.citation.epage4177
dc.identifier.wos000295237400066
dc.identifier.doi10.1016/j.ejmech.2011.06.019
dc.citation.other46(9): 4168-4177
dc.citation.rankM21
dc.identifier.pmid21741132
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-80052929773
dc.identifier.rcubKon_2223


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