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Spektroskopska svojstva i antimikrobna aktivnost dioksomolibden(VI) kompleksa sa heterocikličnim S,S'-ligandima

dc.creatorSovilj, Sofija P.
dc.creatorMitić, Dragana
dc.creatorDrakulić, Branko J.
dc.creatorMilenković, Marina
dc.date.accessioned2018-11-22T00:20:28Z
dc.date.available2018-11-22T00:20:28Z
dc.date.issued2012
dc.identifier.issn0352-5139
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1247
dc.description.abstractFive new dioxomolybdenum(VI) complexes of the general formula [MoO2(Rdtc)(2)], 1-5, where Rdtc(-) refer to piperidine (Pipdtc), 4-morpholine (Morphdtc), 4-thiomorpholine (Timdtc), piperazine (Pzdtc) or N-methylpiperazine (N-Mepzdtc) dithiocarbamates, respectively, have been prepared. The complexes were characterized by elemental analysis, conductometric measurements, electronic, IR and NMR spectroscopy. The complexes 1-5 contain a cis-MoO2 group and have an octahedral geometry. Two dithiocarbamato ions join as bidentates with both the sulfur atoms to the molybdenum atom. The presence of different heteroatoms in the piperidino moiety influences the v(C=N) and v(C=S) vibrations, which wavelengths decrease in the order: Pipdtc gt N-Mepzdtc gt Morphdtc gt Pzdtc gt Timdtc ligands. Based on their spectral data, the molecular structures of complexes 1-5 were optimized at the semi-empirical molecular-orbital level, and the geometries, as obtained from calculations, are described. The antimicrobial activities of the complexes were tested against nine different laboratory control strains of bacteria and two strains of the yeast Candida albicans. All the tested strains were sensitive. Complexes bearing heteroatom in position 4 of piperidine moiety were significantly more potent against the tested bacteria compared to the corresponding ligands.en
dc.description.abstractSintetisano je pet novih dioksomolibden(VI) kompleksa, opšte formule [MoO2(Rdtc-)2], sa Rdtc- ligandima: piperidin- (Pipdtc), 4-morfolin- (Morphdtc), 4-tiomorfolin- (Timdtc), piperazin- (Pzdtc) i N-metilpiperazin- (N-Mepzdtc) ditiokarbamatima. Kompleksi su okarakterisani elementalnom analizom, IR i NMR spektroskopijom kao i merenjem molarne provodljivosti. Pretpostavljena geometrija svih kompleksa je oktaedarska. Rdtc- ligandi su bidentatno koordinovani preko oba atoma sumpora za atom molibdena. Prisustvo različitih heteroatoma utiče na promenu položaja v(C=N) i v(C=S) vibracija, čiji opada sledećim redom liganada: Pipdtc gt N-Mepzdtc gt Morphdt gt Pzdtc gt Timdtc. Na osnovu spektralnih podataka, strukture svih kompleksa su optimizovane na semiempirijskom molekulsko-orbitalnom nivou upotrebom PM6 metoda. Antimikrobna aktivnost ispitivana je na jedanaest različitih patogena. Uočeno je da kompleksi koji imaju heteroatom u položaju 4 piperidinskog prstena ispoljavaju značajno veću jačinu antimikrobnog dejstva prema bakterijama, u poređenju sa odgovarajućim ligandima.sr
dc.publisherSerbian Chemical Soc, Belgrade
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172014/RS//
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectdithiocarbamatesen
dc.subjectmolybdenum(VI) complexesen
dc.subjectmolybdenum(VI) complexesen
dc.subjectMoO22+ groupen
dc.subjectMoO22+ groupen
dc.subjectgeometry optimizationen
dc.subjectgeometry optimizationen
dc.titleSpectroscopic properties and antimicrobial activity of dioxomolybdenum(VI) complexes with heterocyclic S,S '-ligandsen
dc.titleSpektroskopska svojstva i antimikrobna aktivnost dioksomolibden(VI) kompleksa sa heterocikličnim S,S'-ligandimasr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractМиленковиц, Марина; Совиљ, Софија П.; Митиц, Драгана; Дракулиц, Бранко Ј.; Спектроскопска својства и антимикробна активност диоксомолибден(ВИ) комплекса са хетероцикличним С,С'-лигандима; Спектроскопска својства и антимикробна активност диоксомолибден(ВИ) комплекса са хетероцикличним С,С'-лигандима;
dc.citation.volume77
dc.citation.issue1
dc.citation.spage53
dc.citation.epage66
dc.identifier.wos000300386100006
dc.identifier.doi10.2298/JSC110328160S
dc.citation.other77(1): 53-66
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-84858654913
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/8421/1245.pdf
dc.identifier.rcubKon_2269


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