Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects
Samo za registrovane korisnike
2012
Autori
Miljković, ĐorđePoljarević, Jelena
Petkovic, Filip
Blazevski, Jana
Momčilović, Miljana
Nikolic, Ivana
Saksida, Tamara
Stošić-Grujičić, Stanislava D.
Grgurić-Šipka, Sanja
Sabo, Tibor
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
We have recently reported that a novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoato ligand has a potent cytotoxic effect on glioma, melanoma and fibrosarcoma cell lines. In this work, we investigated the influence of the Pt(IV) compound on immune cells. We determined its effect on the viability of spleen cells and lymph node cells and on their capability to produce interferon (IFN)-gamma and interleukin (IL)-17. Also, we researched the compound's impact on peritoneal macrophages and generation of NO in these cells. Our results show that the complex has limited influence on cell viability of immune cells, but profound inhibitory effect on the production of examined immune mediators. These results are valuable as they show that the novel Pt(IV) complex applied in concentrations which are effective against tumor cells do not affect immune cell viability. Moreover, they also imply that the complex has immunomodulatory properties. (C) 2...011 Elsevier Masson SAS. All rights reserved.
Ključne reči:
Bioinorganic chemistry / Platinum / Cytotoxicity / Immunology / CytokinesIzvor:
European Journal of Medicinal Chemistry, 2012, 47, 194-201Izdavač:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
Finansiranje / projekti:
- Racionalni dizajn i sinteza biološki aktivnih i koordinacionih jedinjenja i funkcionalnih materijala, relevantnih u (bio)nanotehnologiji (RS-MESTD-Basic Research (BR or ON)-172035)
- Molekularni mehanizmi fiziološke i farmakološke kontrole inflamacije i kancera (RS-MESTD-Basic Research (BR or ON)-173013)
DOI: 10.1016/j.ejmech.2011.10.042
ISSN: 0223-5234
PubMed: 22071257
WoS: 000301169800021
Scopus: 2-s2.0-84855773005
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Miljković, Đorđe AU - Poljarević, Jelena AU - Petkovic, Filip AU - Blazevski, Jana AU - Momčilović, Miljana AU - Nikolic, Ivana AU - Saksida, Tamara AU - Stošić-Grujičić, Stanislava D. AU - Grgurić-Šipka, Sanja AU - Sabo, Tibor PY - 2012 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1258 AB - We have recently reported that a novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoato ligand has a potent cytotoxic effect on glioma, melanoma and fibrosarcoma cell lines. In this work, we investigated the influence of the Pt(IV) compound on immune cells. We determined its effect on the viability of spleen cells and lymph node cells and on their capability to produce interferon (IFN)-gamma and interleukin (IL)-17. Also, we researched the compound's impact on peritoneal macrophages and generation of NO in these cells. Our results show that the complex has limited influence on cell viability of immune cells, but profound inhibitory effect on the production of examined immune mediators. These results are valuable as they show that the novel Pt(IV) complex applied in concentrations which are effective against tumor cells do not affect immune cell viability. Moreover, they also imply that the complex has immunomodulatory properties. (C) 2011 Elsevier Masson SAS. All rights reserved. PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris T2 - European Journal of Medicinal Chemistry T1 - Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects VL - 47 SP - 194 EP - 201 DO - 10.1016/j.ejmech.2011.10.042 ER -
@article{ author = "Miljković, Đorđe and Poljarević, Jelena and Petkovic, Filip and Blazevski, Jana and Momčilović, Miljana and Nikolic, Ivana and Saksida, Tamara and Stošić-Grujičić, Stanislava D. and Grgurić-Šipka, Sanja and Sabo, Tibor", year = "2012", abstract = "We have recently reported that a novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoato ligand has a potent cytotoxic effect on glioma, melanoma and fibrosarcoma cell lines. In this work, we investigated the influence of the Pt(IV) compound on immune cells. We determined its effect on the viability of spleen cells and lymph node cells and on their capability to produce interferon (IFN)-gamma and interleukin (IL)-17. Also, we researched the compound's impact on peritoneal macrophages and generation of NO in these cells. Our results show that the complex has limited influence on cell viability of immune cells, but profound inhibitory effect on the production of examined immune mediators. These results are valuable as they show that the novel Pt(IV) complex applied in concentrations which are effective against tumor cells do not affect immune cell viability. Moreover, they also imply that the complex has immunomodulatory properties. (C) 2011 Elsevier Masson SAS. All rights reserved.", publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris", journal = "European Journal of Medicinal Chemistry", title = "Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects", volume = "47", pages = "194-201", doi = "10.1016/j.ejmech.2011.10.042" }
Miljković, Đ., Poljarević, J., Petkovic, F., Blazevski, J., Momčilović, M., Nikolic, I., Saksida, T., Stošić-Grujičić, S. D., Grgurić-Šipka, S.,& Sabo, T.. (2012). Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects. in European Journal of Medicinal Chemistry Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 47, 194-201. https://doi.org/10.1016/j.ejmech.2011.10.042
Miljković Đ, Poljarević J, Petkovic F, Blazevski J, Momčilović M, Nikolic I, Saksida T, Stošić-Grujičić SD, Grgurić-Šipka S, Sabo T. Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects. in European Journal of Medicinal Chemistry. 2012;47:194-201. doi:10.1016/j.ejmech.2011.10.042 .
Miljković, Đorđe, Poljarević, Jelena, Petkovic, Filip, Blazevski, Jana, Momčilović, Miljana, Nikolic, Ivana, Saksida, Tamara, Stošić-Grujičić, Stanislava D., Grgurić-Šipka, Sanja, Sabo, Tibor, "Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects" in European Journal of Medicinal Chemistry, 47 (2012):194-201, https://doi.org/10.1016/j.ejmech.2011.10.042 . .