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dc.creatorPejin, Boris
dc.creatorTommonaro, Giuseppina
dc.creatorIodice, Carmine
dc.creatorTešević, Vele
dc.creatorVajs, Vlatka
dc.date.accessioned2018-11-22T00:21:42Z
dc.date.available2018-11-22T00:21:42Z
dc.date.issued2012
dc.identifier.issn1478-6419
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1323
dc.description.abstractAs part of our ongoing project of new acetylcholinesterase inhibitors from lower marine and terrestrial species, a phytochemical investigation was conducted on a foliose lichen, Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), from Bosnia and Herzegovina. The study led to the isolation of a mixture of acetylated depsidones which showed a moderate activity (0.5 mu g) in the acetylcholinesterase inhibition test on Thin-layer chromatography plate. Our results indicate for the first time the significance of depsidones, highly specific metabolites from lichen species, in searching for these inhibitors which still represent the best drugs currently available for the management of Alzheimer's disease.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142053/RS//
dc.rightsrestrictedAccess
dc.sourceNatural Product Research
dc.subjectlichenen
dc.subjectLobaria pulmonariaen
dc.subjectdepsidonesen
dc.subjectacetylcholinesterase inhibition activityen
dc.subjectAlzheimer's diseaseen
dc.titleAcetylcholinesterase inhibition activity of acetylated depsidones from Lobaria pulmonariaen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТоммонаро, Гиусеппина; Пејин, Борис; Тешевић, Веле; Вајс, Влатка; Иодице, Цармине;
dc.citation.volume26
dc.citation.issue17
dc.citation.spage1634
dc.citation.epage1637
dc.identifier.wos000307350800011
dc.identifier.doi10.1080/14786419.2011.585989
dc.citation.other26(17): 1634-1637
dc.citation.rankM23
dc.identifier.pmid21985528
dc.identifier.scopus2-s2.0-84865190526
dc.identifier.rcubKon_2346


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