Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands
Нема приказа
Аутори
Mihajlović-Lalić, LjiljanaStanković, Dalibor
Poljarević, Jelena
Manojlović, Dragan D.
Sabo, Tibor
Grgurić-Šipka, Sanja
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Pt(IV) complexes with ethylenediamine-N,N'-diacetate-type ligands exhibit strong antitumor activity towards various cancer cell lines. In order to explain their complete mechanisms of action, we examined bioreductive character of eight compounds in total using cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. Recorded voltammograms of all Pt(IV) complexes with methyl, ethyl, n-propyl and n-butyl esters of (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid confirmed two successive one-electron transfer steps followed by the loss of the corresponding axial ligands. The redox potential values for Pt(IV) complexes were in the range of -0.92 V lt Ep lt -0.70 V vs. Ag/AgCl, indicating hard reduction. The obtained electrochemical data pointed to the fact that the length of alkyl substituents influences on the reduction as well as on their biological activity. In addition, the electrochemical data were correlated with the biological data b...ut this correlation wasn't established. The reported electrochemical data well correlated with the biological results pointed to the future structural modifications among the investigated compounds and helped select the most suitable candidates for further research.
Кључне речи:
platinum(IV) / anticancer / reduction potential / voltammetryИзвор:
International Journal of Electrochemical Science, 2013, 8, 6, 8433-8441Издавач:
- Esg, Belgrade
Финансирање / пројекти:
- Рационални дизајн и синтеза биолошки активних и координационих једињења и функционалних материјала, релевантних у (био)нанотехнологији (RS-MESTD-Basic Research (BR or ON)-172035)
- Примена унапређених оксидационих процеса и наноструктурисаних оксидних материјала за уклањање загађивача из животне средине, развој и оптимизација инструменталних техника за праћење ефикасности (RS-MESTD-Basic Research (BR or ON)-172030)
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Mihajlović-Lalić, Ljiljana AU - Stanković, Dalibor AU - Poljarević, Jelena AU - Manojlović, Dragan D. AU - Sabo, Tibor AU - Grgurić-Šipka, Sanja PY - 2013 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1392 AB - Pt(IV) complexes with ethylenediamine-N,N'-diacetate-type ligands exhibit strong antitumor activity towards various cancer cell lines. In order to explain their complete mechanisms of action, we examined bioreductive character of eight compounds in total using cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. Recorded voltammograms of all Pt(IV) complexes with methyl, ethyl, n-propyl and n-butyl esters of (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid confirmed two successive one-electron transfer steps followed by the loss of the corresponding axial ligands. The redox potential values for Pt(IV) complexes were in the range of -0.92 V lt Ep lt -0.70 V vs. Ag/AgCl, indicating hard reduction. The obtained electrochemical data pointed to the fact that the length of alkyl substituents influences on the reduction as well as on their biological activity. In addition, the electrochemical data were correlated with the biological data but this correlation wasn't established. The reported electrochemical data well correlated with the biological results pointed to the future structural modifications among the investigated compounds and helped select the most suitable candidates for further research. PB - Esg, Belgrade T2 - International Journal of Electrochemical Science T1 - Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands VL - 8 IS - 6 SP - 8433 EP - 8441 UR - https://hdl.handle.net/21.15107/rcub_cherry_1392 ER -
@article{ author = "Mihajlović-Lalić, Ljiljana and Stanković, Dalibor and Poljarević, Jelena and Manojlović, Dragan D. and Sabo, Tibor and Grgurić-Šipka, Sanja", year = "2013", abstract = "Pt(IV) complexes with ethylenediamine-N,N'-diacetate-type ligands exhibit strong antitumor activity towards various cancer cell lines. In order to explain their complete mechanisms of action, we examined bioreductive character of eight compounds in total using cyclic voltammetry, differential pulse voltammetry and electrochemical impedance spectroscopy. Recorded voltammograms of all Pt(IV) complexes with methyl, ethyl, n-propyl and n-butyl esters of (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid confirmed two successive one-electron transfer steps followed by the loss of the corresponding axial ligands. The redox potential values for Pt(IV) complexes were in the range of -0.92 V lt Ep lt -0.70 V vs. Ag/AgCl, indicating hard reduction. The obtained electrochemical data pointed to the fact that the length of alkyl substituents influences on the reduction as well as on their biological activity. In addition, the electrochemical data were correlated with the biological data but this correlation wasn't established. The reported electrochemical data well correlated with the biological results pointed to the future structural modifications among the investigated compounds and helped select the most suitable candidates for further research.", publisher = "Esg, Belgrade", journal = "International Journal of Electrochemical Science", title = "Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands", volume = "8", number = "6", pages = "8433-8441", url = "https://hdl.handle.net/21.15107/rcub_cherry_1392" }
Mihajlović-Lalić, L., Stanković, D., Poljarević, J., Manojlović, D. D., Sabo, T.,& Grgurić-Šipka, S.. (2013). Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands. in International Journal of Electrochemical Science Esg, Belgrade., 8(6), 8433-8441. https://hdl.handle.net/21.15107/rcub_cherry_1392
Mihajlović-Lalić L, Stanković D, Poljarević J, Manojlović DD, Sabo T, Grgurić-Šipka S. Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands. in International Journal of Electrochemical Science. 2013;8(6):8433-8441. https://hdl.handle.net/21.15107/rcub_cherry_1392 .
Mihajlović-Lalić, Ljiljana, Stanković, Dalibor, Poljarević, Jelena, Manojlović, Dragan D., Sabo, Tibor, Grgurić-Šipka, Sanja, "Electrochemistry and Bioactivity Relationship of Pt(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N '-Diacetate-Type Ligands" in International Journal of Electrochemical Science, 8, no. 6 (2013):8433-8441, https://hdl.handle.net/21.15107/rcub_cherry_1392 .