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dc.creatorŠukalović, Vladimir
dc.creatorBogdan, Anca Elena
dc.creatorTovilović, Gordana
dc.creatorIgnjatović, Đurđica
dc.creatorAndrić, Deana
dc.creatorKostić-Rajačić, Slađana
dc.creatorŠoškić, Vukić
dc.date.accessioned2018-11-22T00:24:09Z
dc.date.available2018-11-22T00:24:09Z
dc.date.issued2013
dc.identifier.issn0365-6233
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1413
dc.description.abstractThe ratio of affinities toward the dopamine D-2 and the 5-hydroxytryptamine 5-HT1A receptors is one of the important parameters that determine the efficiency of antipsychotic drugs. Here, we present the synthesis of ortho-, meta-, and para-N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides and their structure-activity relationship studies on dopamine D-2 and 5-hydroxytryptamine 5-HT1A receptors. It was shown that the biological activity of the described ligands strongly depends on their topology as well as on the nature of the heteroaryl group in the head of the molecules. Docking simulations together with conformational analysis revealed a rational explanation for the ligands' behavior. The molecular model of receptor-ligand interactions described herein provided us with a tool for the rational design of new compounds with a favorable D-2/5-HT1A profile.en
dc.publisherWiley-V C H Verlag Gmbh, Weinheim
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172032/RS//
dc.rightsrestrictedAccess
dc.sourceArchiv der Pharmazie
dc.subjectArylpiperazineen
dc.subjectDopamine receptorsen
dc.subjectSerotonin receptorsen
dc.titleN-{[2-(4-Phenyl-piperazin-1-yl)-ethyl]-phenyl}-arylamides with Dopamine D-2 and 5-Hydroxytryptamine 5HT(1A) Activity: Synthesis, Testing, and Molecular Modelingen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСукаловиц, Владимир; Aндрић, Деана; Богдан, Aнца Елена; Костиц-Рајациц, Сладјана; Товиловиц, Гордана; Соскиц, Вукиц; Игњатовиц, Дјурдјица;
dc.citation.volume346
dc.citation.issue10
dc.citation.spage708
dc.citation.epage717
dc.identifier.wos000325497500002
dc.identifier.doi10.1002/ardp.201300189
dc.citation.other346(10): 708-717
dc.citation.rankM22
dc.identifier.pmid24105736
dc.description.otherSupplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3511]
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-84885595739
dc.identifier.rcubKon_2533


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