The Importance of Cross-Reactivity in Grass Pollen Allergy
2014
Аутори
Aleksić, IvanaVučković, Olga
Smiljanić, Katarina
Gavrović-Jankulović, Marija
Krsmanovic, Vera
Burazer, Lidija M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
According to the data obtained from in vivo and in vitro testing in Serbia, a significant number of patients have allergic symptoms caused by grass pollen. We examined the protein composition of grass pollens (Dactylis glomerata, Lolium perenne and Phleum pratense) and cross-reactivity in patients allergic to grass pollen from our region. The grass pollen allergen extract was characterized by SDS-PAGE, while cross-reactivity of single grass pollens was revealed by immunoblot analysis. A high degree of cross-reactivity was demonstrated for all three single pollens in the sera of allergic patients compared to the grass pollen extract mixture. Confirmation of the existence of cross-reactivity between different antigenic sources facilitates the use of monovalent vaccines, which are easier to standardize and at the same time prevent further sensitization of patients and reduces adverse reactions.
Кључне речи:
allergy / grass pollen / allergens / cross-reactivity / immunotherapyИзвор:
Archives of biological sciences, 2014, 66, 3, 1149-1155Издавач:
- Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd
Финансирање / пројекти:
- Алергени, антитела, ензими и мали физиолошки значајни молекули: дизајн, структура, функција и значај (RS-MESTD-Basic Research (BR or ON)-172049)
- Молекуларне особине и модификације неких респираторних и нутритивних алергена (RS-MESTD-Basic Research (BR or ON)-172024)
DOI: 10.2298/ABS1403149A
ISSN: 0354-4664
WoS: 000346476900025
Scopus: 2-s2.0-84908191590
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Aleksić, Ivana AU - Vučković, Olga AU - Smiljanić, Katarina AU - Gavrović-Jankulović, Marija AU - Krsmanovic, Vera AU - Burazer, Lidija M. PY - 2014 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1478 AB - According to the data obtained from in vivo and in vitro testing in Serbia, a significant number of patients have allergic symptoms caused by grass pollen. We examined the protein composition of grass pollens (Dactylis glomerata, Lolium perenne and Phleum pratense) and cross-reactivity in patients allergic to grass pollen from our region. The grass pollen allergen extract was characterized by SDS-PAGE, while cross-reactivity of single grass pollens was revealed by immunoblot analysis. A high degree of cross-reactivity was demonstrated for all three single pollens in the sera of allergic patients compared to the grass pollen extract mixture. Confirmation of the existence of cross-reactivity between different antigenic sources facilitates the use of monovalent vaccines, which are easier to standardize and at the same time prevent further sensitization of patients and reduces adverse reactions. PB - Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd T2 - Archives of biological sciences T1 - The Importance of Cross-Reactivity in Grass Pollen Allergy VL - 66 IS - 3 SP - 1149 EP - 1155 DO - 10.2298/ABS1403149A ER -
@article{ author = "Aleksić, Ivana and Vučković, Olga and Smiljanić, Katarina and Gavrović-Jankulović, Marija and Krsmanovic, Vera and Burazer, Lidija M.", year = "2014", abstract = "According to the data obtained from in vivo and in vitro testing in Serbia, a significant number of patients have allergic symptoms caused by grass pollen. We examined the protein composition of grass pollens (Dactylis glomerata, Lolium perenne and Phleum pratense) and cross-reactivity in patients allergic to grass pollen from our region. The grass pollen allergen extract was characterized by SDS-PAGE, while cross-reactivity of single grass pollens was revealed by immunoblot analysis. A high degree of cross-reactivity was demonstrated for all three single pollens in the sera of allergic patients compared to the grass pollen extract mixture. Confirmation of the existence of cross-reactivity between different antigenic sources facilitates the use of monovalent vaccines, which are easier to standardize and at the same time prevent further sensitization of patients and reduces adverse reactions.", publisher = "Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd", journal = "Archives of biological sciences", title = "The Importance of Cross-Reactivity in Grass Pollen Allergy", volume = "66", number = "3", pages = "1149-1155", doi = "10.2298/ABS1403149A" }
Aleksić, I., Vučković, O., Smiljanić, K., Gavrović-Jankulović, M., Krsmanovic, V.,& Burazer, L. M.. (2014). The Importance of Cross-Reactivity in Grass Pollen Allergy. in Archives of biological sciences Inst Bioloska Istrazivanja Sinisa Stankovic, Beograd., 66(3), 1149-1155. https://doi.org/10.2298/ABS1403149A
Aleksić I, Vučković O, Smiljanić K, Gavrović-Jankulović M, Krsmanovic V, Burazer LM. The Importance of Cross-Reactivity in Grass Pollen Allergy. in Archives of biological sciences. 2014;66(3):1149-1155. doi:10.2298/ABS1403149A .
Aleksić, Ivana, Vučković, Olga, Smiljanić, Katarina, Gavrović-Jankulović, Marija, Krsmanovic, Vera, Burazer, Lidija M., "The Importance of Cross-Reactivity in Grass Pollen Allergy" in Archives of biological sciences, 66, no. 3 (2014):1149-1155, https://doi.org/10.2298/ABS1403149A . .