Hyperatomarin, an antibacterial prenylated phloroglucinol from Hypericum atomarium ssp degenii
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shown by quantitative H-1 NMR measurements, a lipophilic extract of the aerial parts of Hypericum atomarium ssp. degenii contained a high percentage (3.1% per weight of dried plant material) of a prenylated phloroglucinol (1). Compound 1, named hyperatomarin, occurring in two tautomeric forms (1a reversible arrow 1b), was isolated by bioactivity-guided preparative TLC and was identified on the basis of spectral data interpretation. This isolated phloroglucinol exhibited activity against Gram-positive (Staphyloccocus aureus and Microccocus luteus) and Gram-positive spore-forming bacteria (Bacillus subtilis and B. IP 5832).
Source:Journal of Natural Products, 2003, 66, 9, 1236-1238
- Amer Chemical Soc, Washington