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dc.creatorRakic, Gordana M.
dc.creatorGrgurić-Šipka, Sanja
dc.creatorKaluđerović, Goran N.
dc.creatorBette, Martin
dc.creatorFilipovic, Lana
dc.creatorArandelovic, Sandra
dc.creatorRadulović, Siniša S.
dc.creatorTešić, Živoslav Lj.
dc.date.accessioned2018-11-22T00:22:03Z
dc.date.available2018-11-22T00:22:03Z
dc.date.issued2012
dc.identifier.issn0223-5234
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1537
dc.description.abstractPlatinum(IV) complexes with general formulas [Pt(L1-2)(2)Cl-4]. where L1-2 are 3-acetylpyridine (1) and 4-acetylpyridine (2) respectively, and [Pt(HL3-5)(2)Cl-2], where H2L3-5 are 2,3-pyridinedicarboxylic acid (3), 2,4-pyridinedicarboxylic acid (4) and 2,5-pyridinedicarboxylic acid (5) respectively, were prepared by the reaction of K-2[PtCl6] with the corresponding ligand in 1:2 M ratio in water. The complexes were characterized by elemental analysis and IR and NMR spectroscopy. The structures of complexes 2 and 5 were determined by X-ray crystallography, which revealed the trans orientation of chloride anions around platinum(IV) in the case of both complexes. The antiproliferative activity was investigated in six tumor cell lines (human cervical carcinoma cells (HeLa), murine melanoma cells (B16), human breast carcinoma cells (MDA-MB-453), human colon carcinoma cells (LS-174), transformed human umbilical vein endothelial cells (EA.hy 926) and murine endothelial cells (MS1)) and in one non-tumor cell line-human fetal lung fibroblast cells (MRC-5). Cytotoxicity studies indicated that Pt(IV) complexes with acetyl-substituted pyridine ligands exhibit significantly higher in vitro antiproliferative activity than the complexes with carboxylato-substituted pyridines. Complexes 1 and 2 showed antiproliferative activity in all tested tumor cell lines, with the highest potential in human endothelial cells EA.hy 926, since they had IC50 values of 13.8 +/- 5.8 mu M and 23.4 +/- 3.3 mu M, respectively and were more active than cisplatin. Complexes 1 and 2 exhibited lower toxicity against the non-tumor human lung fibroblast cell line (MRC-5) than against most of the tested tumor cell lines. (C) 2012 Elsevier Masson SAS. All rights reserved.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172017/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectPt(IV) complexesen
dc.subjectPyridine derivativesen
dc.subjectDFTen
dc.subjectX-rayen
dc.subjectCytotoxicityen
dc.subjectEA.hy 926en
dc.titleThe synthesis, spectroscopic, X-ray characterization and in vitro cytotoxic testing results of activity of five new trans-platinum(IV) complexes with functionalized pyridinesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГргурић-Шипка, Сања; Ракиц, Гордана М.; Бетте, Мартин; Тешић, Живослав Љ.; Калудеровиц, Горан Н.; Радуловиц, Синиса; Aранделовиц, Сандра; Филиповиц, Лана;
dc.citation.volume55
dc.citation.spage214
dc.citation.epage219
dc.identifier.wos000309494100023
dc.identifier.doi10.1016/j.ejmech.2012.07.019
dc.citation.other55: 214-219
dc.citation.rankM21
dc.identifier.pmid22858225
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-84865759718
dc.identifier.rcubKon_2368


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