Sensitive Determination of the Indole Alkaloid Reserpine Using a Glassy Carbon Based Electrochemical Sensor
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In the present paper a glassy carbon electrode was successfully applied for the sensitive and selective determination of the indole alkaloid reserpine by differential pulse voltammetry (DPV). The electrochemical behavior of reserpine was investigated using cyclic voltammetry and best conditions for its quantification were examined by differential pulse voltammetry. Cyclic voltammetry has shown that the oxidation process is irreversible over the pH range 1 - 12 and that the electrode process is mainly diffusion controlled. The proposed procedure has wide linear concentration range for determination of reserpine by DPV from 2 mu M to 75 mu M with a detection limit 0.6 mu M. The sensor in combination with optimized electrochemical parameters was successfully applied for the determination of reserpine in model human urine with good recovery.
Keywords:Reserpine / glassy carbon electrode / differential pulse voltammetry / human urine sample
Source:International Journal of Electrochemical Science, 2015, 10, 2, 1469-1477
- Esg, Belgrade
- Application of advanced oxidation processes and nanostructured oxide materials for the removal of pollutants from the environment, development and optimisation of instrumental techniques for efficiency monitoring (RS-172030)
- Grant Agency of the Slovak Republic [1/0051/13]