Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater
Само за регистроване кориснике
2015
Аутори
Paiga, PaulaLolić, Aleksandar
Hellebuyck, Floris
Santos, Lucia H. M. L. M.
Correia, Manuela
Delerue-Matos, Cristina
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (SPE-UHPLC-MS/MS). Extraction conditions were optimized taking into account parameters like sorbent material, sample volume and sample pH. Method detection limits (MDLs) ranging from 0.02 to 8.18 ng/L were obtained. This methodology was successfully applied to the determination of the selected pharmaceuticals in seawater samples of Atlantic Ocean in the Northern Portuguese coast. All the pharmaceuticals have been detected in the seawater samples, with pharmaceuticals like ibuprofen, acetaminophen, ketoprofen and the metabolite hydroxyibuprofen being the most frequently detected at concentrations that can reach some hundreds of ng/L.
Кључне речи:
Non-steroidal anti-inflammatory drugs / Analgesics / UHPLC-MS/MS / SPE / SeawaterИзвор:
Journal of Pharmaceutical and Biomedical Analysis, 2015, 106, 61-70Издавач:
- Elsevier Science Bv, Amsterdam
Финансирање / пројекти:
- national funds through FCT - Foundation for Science and Technology [PEst-C/EQB/LA0006/2013, PEst-C/MAR/LA0015/2011]
- European Regional Development Fund (ERDF) through the COMPETE - Operational Competitiveness Programme
Напомена:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3362
DOI: 10.1016/j.jpba.2014.06.017
ISSN: 0731-7085
PubMed: 25002040
WoS: 000351117100008
Scopus: 2-s2.0-84923327567
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Paiga, Paula AU - Lolić, Aleksandar AU - Hellebuyck, Floris AU - Santos, Lucia H. M. L. M. AU - Correia, Manuela AU - Delerue-Matos, Cristina PY - 2015 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1674 AB - An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (SPE-UHPLC-MS/MS). Extraction conditions were optimized taking into account parameters like sorbent material, sample volume and sample pH. Method detection limits (MDLs) ranging from 0.02 to 8.18 ng/L were obtained. This methodology was successfully applied to the determination of the selected pharmaceuticals in seawater samples of Atlantic Ocean in the Northern Portuguese coast. All the pharmaceuticals have been detected in the seawater samples, with pharmaceuticals like ibuprofen, acetaminophen, ketoprofen and the metabolite hydroxyibuprofen being the most frequently detected at concentrations that can reach some hundreds of ng/L. PB - Elsevier Science Bv, Amsterdam T2 - Journal of Pharmaceutical and Biomedical Analysis T1 - Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater VL - 106 SP - 61 EP - 70 DO - 10.1016/j.jpba.2014.06.017 ER -
@article{ author = "Paiga, Paula and Lolić, Aleksandar and Hellebuyck, Floris and Santos, Lucia H. M. L. M. and Correia, Manuela and Delerue-Matos, Cristina", year = "2015", abstract = "An analytical methodology for the simultaneous determination of seven pharmaceuticals and two metabolites belonging to the non-steroidal anti-inflammatory drugs (NSAIDs) and analgesics therapeutic groups was developed based on off-line solid-phase extraction and ultra-high performance liquid chromatography coupled to tandem mass spectrometry (SPE-UHPLC-MS/MS). Extraction conditions were optimized taking into account parameters like sorbent material, sample volume and sample pH. Method detection limits (MDLs) ranging from 0.02 to 8.18 ng/L were obtained. This methodology was successfully applied to the determination of the selected pharmaceuticals in seawater samples of Atlantic Ocean in the Northern Portuguese coast. All the pharmaceuticals have been detected in the seawater samples, with pharmaceuticals like ibuprofen, acetaminophen, ketoprofen and the metabolite hydroxyibuprofen being the most frequently detected at concentrations that can reach some hundreds of ng/L.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Journal of Pharmaceutical and Biomedical Analysis", title = "Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater", volume = "106", pages = "61-70", doi = "10.1016/j.jpba.2014.06.017" }
Paiga, P., Lolić, A., Hellebuyck, F., Santos, L. H. M. L. M., Correia, M.,& Delerue-Matos, C.. (2015). Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. in Journal of Pharmaceutical and Biomedical Analysis Elsevier Science Bv, Amsterdam., 106, 61-70. https://doi.org/10.1016/j.jpba.2014.06.017
Paiga P, Lolić A, Hellebuyck F, Santos LHMLM, Correia M, Delerue-Matos C. Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater. in Journal of Pharmaceutical and Biomedical Analysis. 2015;106:61-70. doi:10.1016/j.jpba.2014.06.017 .
Paiga, Paula, Lolić, Aleksandar, Hellebuyck, Floris, Santos, Lucia H. M. L. M., Correia, Manuela, Delerue-Matos, Cristina, "Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater" in Journal of Pharmaceutical and Biomedical Analysis, 106 (2015):61-70, https://doi.org/10.1016/j.jpba.2014.06.017 . .