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dc.creatorMarzo, Tiziano
dc.creatorSavić, Aleksandar
dc.creatorMassai, Lara
dc.creatorMichelucci, Elena
dc.creatorSabo, Tibor
dc.creatorGrgurić-Šipka, Sanja
dc.creatorMessori, Luigi
dc.date.accessioned2018-11-22T00:31:02Z
dc.date.available2018-11-22T00:31:02Z
dc.date.issued2015
dc.identifier.issn0966-0844
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1683
dc.description.abstractThe reactions of four representative metallodrugs with the model protein HEWL were investigated within a non-aqueous environment-i.e. in pure DMSO- through UV-Vis absorption spectroscopy and ESI MS analysis. Notably, formation of a variety of metallodrug-protein adducts was clearly documented. This is the first example for this kind of protein metalation reactions carried out within a pure organic solvent. It is shown that the applied solution conditions greatly affect the nature of the formed adducts, this being well accounted for by the fact that the overall protein conformation is greatly perturbed within pure DMSO; in addition, the activation profiles of the studied metallodrugs are also highly dependent on the nature of the solvent. The implications of these results are discussed.en
dc.publisherSpringer, Dordrecht
dc.relationCOST ACTION [CM-1105]
dc.relationCIRCMSB
dc.relationBeneficentia Stiftung
dc.rightsrestrictedAccess
dc.sourceBiometals
dc.subjectAnticancer complexesen
dc.subjectProtein interactionen
dc.subjectLysozymeen
dc.subjectESI-MSen
dc.subjectMetallodrugsen
dc.titleReactions of cytotoxic metallodrugs with lysozyme in pure DMSO explored through UV-Vis absorption spectroscopy and ESI MSen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМессори, Луиги; Гргурић-Шипка, Сања; Сабо, Тибор; Савић, Aлександар; Марзо, Тизиано; Массаи, Лара; Мицхелуцци, Елена;
dc.citation.volume28
dc.citation.issue2
dc.citation.spage425
dc.citation.epage430
dc.identifier.wos000351745200016
dc.identifier.doi10.1007/s10534-015-9839-7
dc.citation.other28(2): 425-430
dc.citation.rankM23~
dc.identifier.pmid25715906
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-84939973054
dc.identifier.rcubKon_2829


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