Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation
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Mitrović, Aleksandra D.
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Ferrocene-substituted porphyrin RL-91 exhibits antifungal activity against opportune human pathogen Candida albicans. RL-91 efficiently inhibits growth of both planktonic C albicans cells and cells within biofilms without photoactivation. The minimal inhibitory concentration for plankton form (PMIC) was established to be 100 mu g/mL and the same concentration killed 80% of sessile cells in the mature biofilm (SMIC80). Furthermore PMIC of RL-91 efficiently prevents C albicans biofilm formation. RL-91 is cytotoxic for human fibroblasts in vitro in concentration of 10 mu g/mL, however it does not cause hemolysis in concentrations of up to 50 mu g/mL. These findings open possibility for application of RL-91 as an antifungal agent for external antibiofilm treatment of medical devices as well as a scaffold for further development of porphyrin based systemic antifungals. (C) 2014 Elsevier Ltd. All rights reserved.
Keywords:Antifungal / Porphyrins / Candida albicans / Biofilm / Ferrocene
Source:Bioorganic and Medicinal Chemistry Letters, 2014, 24, 15, 3506-3511
- Pergamon-Elsevier Science Ltd, Oxford
- Microbial diversity study and characterization of beneficial environmental microorganisms (RS-173048)
- University Erlangen-Nurnberg (Emerging Field Initiative: Medicinal Redox Inorganic Chemistry)