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dc.creatorMarković, Violeta
dc.creatorDebeljak, Nevena
dc.creatorStanojković, Tatjana
dc.creatorKolundzija, Branka
dc.creatorSladić, Dušan
dc.creatorVujčić, Miroslava
dc.creatorJanović, Barbara
dc.creatorTanić, Nikola
dc.creatorPerovic, Milka
dc.creatorTesic, Vesna
dc.creatorAntic, Jadranka
dc.creatorJoksović, Milan D.
dc.date.accessioned2018-11-22T00:32:24Z
dc.date.available2018-11-22T00:32:24Z
dc.date.issued2015
dc.identifier.issn0223-5234
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1903
dc.description.abstractNovel anthraquinone based chalcone compounds were synthesized starting from 1-acetylanthraquinone in a Claisen-Schmidt reaction and evaluated for their anticancer potential against three human cancer cell lines. Compounds 4a, 4b and 4j showed promising activity in inhibition of HeLa cells with IC50 values ranging from 2.36 to 2.73 mu M and low cytotoxicity against healthy MRC-5 cell lines. The effects that compounds produces on the cell cycle were investigated by flow cytometry. It was found that 4a, 4b and 4j cause the accumulation of cells in the S and G2/M phases in a dose-dependent manner and induce caspase-dependent apoptosis. All of three compounds exhibit calf thymus DNA-binding activity. The determined binding constants by absorption titrations (2.65 x 10(3) M-1, 1.36 x 10(3) M(-1)and 2.51 x 10(3) M-1 of 4a/CT-DNA, 4b/CT-DNA and 4j/CT-DNA, respectively) together with fluorescence displacement analysis designate 4a, 4b and 4j as strong minor groove binders, but no cleavage of plasmid DNA was observed. (C) 2014 Elsevier Masson SAS. All rights reserved.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Paris
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173056/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectChalconeen
dc.subjectAnthraquinoneen
dc.subjectCytotoxicityen
dc.subjectApoptosisen
dc.subjectDNA studyen
dc.titleAnthraquinone-chalcone hybrids: Synthesis, preliminary antiproliferative evaluation and DNA-interaction studiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВујциц, Мирослава; Aнтиц, Јадранка; Марковиц, Виолета; Сладић, Душан; Станојковиц, Татјана; Тесиц, Весна; Дебељак, Невена; Колундзија, Бранка; Таниц, Никола; Јоксовиц, Милан Д.; Јановиц, Барбара; Перовиц, Милка;
dc.citation.volume89
dc.citation.spage401
dc.citation.epage410
dc.identifier.wos000348003500036
dc.identifier.doi10.1016/j.ejmech.2014.10.055
dc.citation.other89: 401-410
dc.citation.rankM21
dc.identifier.pmid25462255
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-84908368917
dc.identifier.rcubKon_2786


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