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dc.creatorČobeljić, Božidar
dc.creatorMilenković, Milica R.
dc.creatorPevec, Andrej
dc.creatorTurel, Iztok
dc.creatorVujčić, Miroslava
dc.creatorJanović, Barbara
dc.creatorGligorijević, Nevenka
dc.creatorSladić, Dušan
dc.creatorRadulović, Siniša S.
dc.creatorJovanović, Katarina
dc.creatorAnđelković, Katarina K.
dc.date.accessioned2018-11-22T00:34:28Z
dc.date.available2018-11-22T00:34:28Z
dc.date.issued2016
dc.identifier.issn0949-8257
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1906
dc.description.abstractSquare-planar azido Ni(II) complex with condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent was synthesized and its crystal structure was determined. Cytotoxic activity of the azido complex and previously synthesized isothiocyanato, cyanato and chlorido Ni(II) complexes with this ligand was examined on six tumor cell lines (HeLa, A549, K562, MDA-MB-453, MDA-MB-361 and LS-174) and two normal cell line (MRC-5 and BEAS-2B). All the investigated nickel(II) complexes were cytotoxic against all tumor cell lines. The newly synthesized azido complex showed selectivity to HeLa and A549 tumor cell lines compared to the normal cells (for A549 IC50 was similar to that of cisplatin). Azido complex interferes with cell cycle phase distribution of A549 and HeLa cells and possesses nuclease activity towards supercoiled DNA. The observed selectivity of the azido complex for some tumor cell lines can be connected with its strong DNA damaging activity.en
dc.publisherSpringer, New York
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.relationSlovenian Research Agency (ARRS) [P-0175]
dc.rightsrestrictedAccess
dc.sourceJournal of Biological Inorganic Chemistry
dc.subjectNickel(II) complexesen
dc.subjectGirard's T reagenten
dc.subjectPhosphine ligandsen
dc.subjectCytotoxicityen
dc.subjectDNA interactionsen
dc.titleInvestigation of antitumor potential of Ni(II) complexes with tridentate PNO acylhydrazones of 2-(diphenylphosphino)benzaldehyde and monodentate pseudohalidesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиленковић, Милица; Јовановиц, Катарина; Радуловиц, Синиса; Глигоријевиц, Невенка; Турел, Изток; Певец, Aндреј; Сладић, Душан; Вујциц, Мирослава; Чобељић, Божидар; Јановиц, Барбара; Aнђелковић, Катарина;
dc.citation.volume21
dc.citation.issue2
dc.citation.spage145
dc.citation.epage162
dc.identifier.wos000373018700002
dc.identifier.doi10.1007/s00775-015-1315-x
dc.citation.other21(2): 145-162
dc.citation.rankM22
dc.identifier.pmid26612231
dc.description.otherSupplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3547]
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-84948420892
dc.identifier.rcubKon_3025


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