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Conserved Structural Motif for Recognizing Nicotinamide Adenine Dinucleotide in Poly(ADP-ribose) Polymerases and ADP-Ribosylating Toxins: Implications for Structure-Based Drug Design
(Amer Chemical Soc, Washington, 2010)
The ADP-ribosylating toxins (ADPRTs) and poly(ADP-ribose) polymerases (PARPs) are two important drug target protein families. Although the Y-X(10)-Y motif for the diphtheria toxin group and the STS motif for the other ...
Synthesis, Cytotoxic Activity, and Thermal Studies of Novel N-[(1,3-Diphenylpyrazol-4-yl)methyl] alpha-Amino Acids
(Wiley-Blackwell, Malden, 2010)
New N-[(1,3-diphenylpyrazol-4-yl)methyl]alpha-amino acids (1a-i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT-29, cervix ...
Insights into proteolytic processing of the major peanut allergen Ara h 2 by endogenous peanut proteases
(John Wiley & Sons Ltd, Chichester, 2010)
BACKGROUND: The major peanut allergens are Ara h 1, Ara h 2 and Ara h 6. Proteolytic processing has been shown to be required for the maturation process of Ara h 6. The aim of this study was to examine whether Ara h 2 ...
Possible Sources of Heavy Metals in Urban Soils: Example from Belgrade, Serbia
(Scibulcom Ltd, Sofia, 2010)
The content of heavy metals over time has been continuously increasing in urban soils as a consequence of industrialisation and often unclear sets of environmental controls and protection procedures. However, the role of ...
Cyclohexane oxidation and cyclohexyl hydroperoxide decomposition by poly(4-vinylpyridine-co-divinylbenzene) supported cobalt and chromium complexes
(Elsevier Science Sa, Lausanne, 2010)
Polymer supported catalysts with Co(II) and Cr(VI) ions were prepared and characterized by means of FTIR, diffuse reflectance UV-vis, nitrogen physisorption, mercury porosimetry and SEM-EDX measurements. The catalytic ...
DFT study of the Jahn-Teller effect in Cu(II) chelate complexes
(Elsevier Science Bv, Amsterdam, 2010)
Density functional theory (DFT) in conjunction with the intrinsic distortion path (IDP) is employed to study the Jahn-Teller (JT) effect in all four diastereoisomers of tris(ethylenediamine)copper(II) ([Cu(en)(3)](2+)) and ...
Purification and characterisation of Saccharomyces cerevisiae external invertase isoforms
(Elsevier Sci Ltd, Oxford, 2010)
Four external invertase isoforms (EINV1, EINV2, EINV3 and EINV4) from Saccharomyces cerevisiae were highly purified by isoelectric precipitation, ethanol precipitation, ion-exchange on QAE-Sephadex and gel filtration using ...
Evaluation of the thermal stability and digestibility of heterologously produced banana lectin
(Elsevier Sci Ltd, Oxford, 2010)
The thermal stability of recombinant mannose-specific banana lectin (rBanLec), as well as its stability under conditions of simulated gastro-intestinal fluid (SGF), was investigated. rBanLec was heterologously produced in ...
Electrogenerated chemiluminescence in an electrodeposited redox polymer
(John Wiley & Sons Ltd, Chichester, 2010)