Приказ основних података о документу

dc.creatorSelaković, Života
dc.creatorSoloveva, Veronica
dc.creatorGharaibeh, Dima N.
dc.creatorWells, Jay
dc.creatorŠegan, Sandra B.
dc.creatorPanchal, Rekha G.
dc.creatorŠolaja, Bogdan A.
dc.date.accessioned2018-11-22T00:33:31Z
dc.date.available2018-11-22T00:33:31Z
dc.date.issued2015
dc.identifier.issn2373-8227
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/2035
dc.description.abstractHerein we report on a diazachrysene class of small molecules that exhibit potent antiviral activity against the Ebola (EBOV) virus. The antiviral compounds are easily synthesized, and the most active compounds have excellent in vitro activity (0.34-0.70 mu M) and are significantly less lipophilic than their predecessors. The three most potent diazachrysene antivirals do not exhibit any toxicity in vivo and protected 70-90% of the mice at 10 mg/kg following EBOV challenge. Together, these studies suggest that diazachrysenes are a promising class of compounds for hit to lead optimization and as potential Ebola therapeutics.en
dc.publisherAmer Chemical Soc, Washington
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172008/RS//
dc.relationDepartment of Defense Chemical Biological Defense Program through Defense Threat Reduction Agency (DTRA)
dc.rightsrestrictedAccess
dc.sourceACS INFECTIOUS DISEASES
dc.subjectEbola virusen
dc.subjectantiviral diazachrysenesen
dc.subjectinhibitory efficacy small moleculeen
dc.subjecttoxicityen
dc.titleAnti-Ebola Activity of Diazachrysene Small Moleculesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГхараибех, Дима Н.; Wеллс, Јаy; Панцхал, Рекха Г.; Сеган, Сандра; Селаковић, Живота; Шолаја, Богдан A.; Соловева, Вероница;
dc.citation.volume1
dc.citation.issue6
dc.citation.spage264
dc.citation.epage271
dc.identifier.wos000368463600005
dc.identifier.doi10.1021/acsinfecdis.5b00028
dc.citation.other1(6): 264-271
dc.identifier.pmid27622742
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-84969135965
dc.identifier.rcubKon_2990


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Приказ основних података о документу