Interaction of dinuclear cadmium(II) 5-Cl-salicylaldehyde complexes with calf-thymus DNA
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Hatzidimitriou, Antonios G.
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Five dinuclear Cd(II) complexes with the anion of 5-Cl-salicylaldehyde (5-Cl-saloH) were synthesized in the absence or presence of the alpha-diimines: 2,2'-bipyridine (bipy), 1,10-phenanthroline (phen), 2,9-dimethyl-1,10-henanthroline (neoc) or 2,2'-dipyridylamine (dpamH) and characterized as [Cd(5-Cl-salo)(2)(CH3OH)](2) (1), [Cd(5-Cl-salo)(2)(bipy)](2) (2), [Cd(5-Cl-salo)(2)(phen)](2) (3), [Cd(5-Cl-salo)(neoc)(ONO2)](2) (4) and [Cd(5-Cl-salo)(dpamH)(ONO2)](2) (5). The complexes were characterized by spectroscopic techniques (IR, UV-vis, H-1-NMR and C-13-NMR), elemental analysis and molar conductivity measurements. The structures of four complexes (1-3 and 5) were determined by X-ray crystallography, providing all three possible coordination modes of the ligand 5-Cl-salicylaldehyde, i.e. bidentate or tridentate chelating and/or bridging mode. The complexes bind to calf-thymus (Cr) DNA mainly by intercalation, as concluded by the viscosity measurements and present relatively high DNA-bi...nding constants. The complexes exhibit significant ability to displace ethidium bromide (EB) from the EB-DNA complex, thus indirectly proving the intercalation as the most possible binding mode to Cr DNA. (C) 2016 Elsevier B.V. All rights reserved.
Keywords:Cadmium(II) complexes / Crystal structure / Interaction with calf-thymus DNA / 5-Cl-salicylaldehyde
Source:Materials Science and Engineering. C: Materials for Biological Applications, 2016, 61, 579-590
- Elsevier Science Bv, Amsterdam
- Aristeia, Aristotle University of Thessaloniki
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3544