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dc.creatorSamardžić, Stevan
dc.creatorArsenijević, Jelena
dc.creatorBožić, Dragana
dc.creatorMilenković, Marina
dc.creatorTešević, Vele
dc.creatorMaksimović, Zoran
dc.date.accessioned2018-11-22T00:42:57Z
dc.date.available2018-11-22T00:42:57Z
dc.date.issued2018
dc.identifier.issn0378-8741
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/2068
dc.description.abstractEthnopharmacological relevance: Meadowsweet (Filipendula ulmaria (L.) Maxim.) and dropwort (Filipendula vulgaris Moench) are herbaceous perennials employed in folk medicine for their antirheumatic, antipyretic and antiulcer properties. Aim of the study: To assess ethnomedicinal claims through investigation of antioxidant, anti-inflammatory and gastroprotective effects of F. ulmaria and F. vulgaris lyophilized flower infusions (LFIs) as well as the F. vulgaris isolated flavonoids spiraeoside, kaempferol 4'-O-glucoside, astragalin 2'-O-gallate, mixture of hyperoside 2'-O-gallate and isoquercitrin 2'-O-gallate, and a tannin tellimagrandin IL Materials and methods: Free radical scavenging activity of the tested samples was determined by examining their ability to neutralize DPPH and OH radicals in vitro, whereas reducing properties were assessed in Ferric Reducing Antioxidant Power (FRAP) assay. Anti-inflammatory activity was studied ex vivo in human platelets by monitoring the effect on eicosanoid biosynthesis.. Gastroprotective action was estimated in animal model of acute gastric injury induced by ethanol. Results: LFIs and spiraeoside exerted activities comparable to those of positive control in DPPH-radical scavenging and FRAP antioxidant assays, whereas notable hydroxyl radical scavenging ability was demonstrated only for spiraeoside (IC50 = 5.1 mu g/mL). Among tested samples, astragalin 2 ''-O-gallate (IC50 = 141.1 mu g/mL) and spiraeoside (IC50 = 4.69 mu g/mL) the most markedly inhibited production of pro -inflammatory prostaglandin E-2 and 12(S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid in human platelets, respectively. Examination of LFIs (100-300 mg/kg, p.o.) gastroprotective action in rats revealed their capacity to preserve mucosal integrity. In addition, spiraeoside (50 mg/kg, p.o.) and tellimagrandin II (40 mg/kg, p.o.) showed ulcer preventive ability. Conclusion: Current study supports documented traditional use of investigated herbs and indicates that flavonoid and tannin components are partially responsible for the demonstrated pharmacological activities.en
dc.publisherElsevier Ireland Ltd, Clare
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173021/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Ethnopharmacology
dc.subjectFilipendulaen
dc.subjectMeadowsweeten
dc.subjectDropworten
dc.subjectAntioxidanten
dc.subjectAnti-inflammatoryen
dc.subjectGastroprotectiveen
dc.titleAntioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moenchen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиленковиц, Марина; Максимовиц, Зоран; Бозиц, Драгана; Тешевић, Веле; Самардзиц, Стеван; Aрсенијевиц, Јелена;
dc.citation.volume213
dc.citation.spage132
dc.citation.epage137
dc.identifier.wos000419930700016
dc.identifier.doi10.1016/j.jep.2017.11.013
dc.citation.other213: 132-137
dc.citation.rankM21
dc.identifier.pmid29132911
dc.description.otherPeer-reviewed manuscript: [http://cherry.chem.bg.ac.rs/handle/123456789/3153]
dc.description.otherSupplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3154]
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-85034735455
dc.identifier.rcubKon_3399


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