Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines
Abstract
Acid-base equilibria in heterogeneous and homogeneous systems of some sparingly soluble benzodiazepines (diazepam, prazepam, chlordiazepoxide and medazepam) were investigated in aqueous solution and the corresponding equilibrium constants were determined by the application of pH-metric, spectrophotometric and solubility methods. The sites of protonation were predicted on the basis of the analysis of the corresponding carbon-13 nuclear magnetic resonance spectra. In addition, buffer characteristics of saturated aqueous solutions of these drugs in the presence of the solid phase were investigated and it was established that they possess a very high buffer capacity over a specific pH range.
Keywords:
1,4-Benzodiazepine / Acid-base equilibria / Heterogeneous equilibria / Monoprotic base / Two-phase bufferSource:
Analyst, 1990, 115, 4, 383-387Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Pfendt, Lidija B. AU - Sladić, Dušan AU - Janjić, Tomislav J. AU - Popović, Gordana V. PY - 1990 UR - https://cherry.chem.bg.ac.rs/handle/123456789/20 AB - Acid-base equilibria in heterogeneous and homogeneous systems of some sparingly soluble benzodiazepines (diazepam, prazepam, chlordiazepoxide and medazepam) were investigated in aqueous solution and the corresponding equilibrium constants were determined by the application of pH-metric, spectrophotometric and solubility methods. The sites of protonation were predicted on the basis of the analysis of the corresponding carbon-13 nuclear magnetic resonance spectra. In addition, buffer characteristics of saturated aqueous solutions of these drugs in the presence of the solid phase were investigated and it was established that they possess a very high buffer capacity over a specific pH range. T2 - Analyst T1 - Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines VL - 115 IS - 4 SP - 383 EP - 387 DO - 10.1039/an9901500383 ER -
@article{ author = "Pfendt, Lidija B. and Sladić, Dušan and Janjić, Tomislav J. and Popović, Gordana V.", year = "1990", abstract = "Acid-base equilibria in heterogeneous and homogeneous systems of some sparingly soluble benzodiazepines (diazepam, prazepam, chlordiazepoxide and medazepam) were investigated in aqueous solution and the corresponding equilibrium constants were determined by the application of pH-metric, spectrophotometric and solubility methods. The sites of protonation were predicted on the basis of the analysis of the corresponding carbon-13 nuclear magnetic resonance spectra. In addition, buffer characteristics of saturated aqueous solutions of these drugs in the presence of the solid phase were investigated and it was established that they possess a very high buffer capacity over a specific pH range.", journal = "Analyst", title = "Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines", volume = "115", number = "4", pages = "383-387", doi = "10.1039/an9901500383" }
Pfendt, L. B., Sladić, D., Janjić, T. J.,& Popović, G. V.. (1990). Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines. in Analyst, 115(4), 383-387. https://doi.org/10.1039/an9901500383
Pfendt LB, Sladić D, Janjić TJ, Popović GV. Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines. in Analyst. 1990;115(4):383-387. doi:10.1039/an9901500383 .
Pfendt, Lidija B., Sladić, Dušan, Janjić, Tomislav J., Popović, Gordana V., "Study of heterogeneous equilibria in saturated aqueous solutions of some 7-chloro-1,4-benzodiazepines" in Analyst, 115, no. 4 (1990):383-387, https://doi.org/10.1039/an9901500383 . .