Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives
2018
Аутори
Zukic, SelmaVeljović, Elma
Špirtović-Halilović, Selma
Muratovic, Samija
Osmanović, Amar
Trifunović, Snežana S.
Novaković, Irena T.
Završnik, Davorka
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Ten biologically active 2,2,5,5-tetramethy1-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized and their structures were confirmed by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Synthesized compounds were scanned for their antioxidant, antimicrobial and antiproliferative activity. Antibacterial activity was tested by the diffusion and dilution method against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, while a ntifunga I activity was tested against Candida albicans and Saccharomyces cerevisiae. Antiproliferative activity was tested against HeLa (cervical carcinoma), SW620 (colorectal adenocarcinoma, metastatic), hepatocellular carcinoma (HEpG2), lung carcinoma cells (A549) and mouse embryo fibroblast cell line (3T3). The best antioxidant activity showed compound 2 with two hydroxy groups substituted on phenyl ring in positions 2' and 3'. The best antimicrobial activity of all synthesized compounds s...howed compound 8, while the best antiproliferative activity showed compound 6. Results signify the importance of xanthene-1,8-dione derivatives as potential antioxidant and antiproliferative agents.
Кључне речи:
xanthene-1,8-diones / antimicrobial activity / antiproliferative activity / antioxidant potencyИзвор:
Croatica Chemica Acta, 2018, 91, 1, 1-9Издавач:
- Croatian Chemical Soc, Zagreb
DOI: 10.5562/cca3225
ISSN: 0011-1643
WoS: 000447334900001
Scopus: 2-s2.0-85047193004
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Zukic, Selma AU - Veljović, Elma AU - Špirtović-Halilović, Selma AU - Muratovic, Samija AU - Osmanović, Amar AU - Trifunović, Snežana S. AU - Novaković, Irena T. AU - Završnik, Davorka PY - 2018 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2231 AB - Ten biologically active 2,2,5,5-tetramethy1-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized and their structures were confirmed by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Synthesized compounds were scanned for their antioxidant, antimicrobial and antiproliferative activity. Antibacterial activity was tested by the diffusion and dilution method against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, while a ntifunga I activity was tested against Candida albicans and Saccharomyces cerevisiae. Antiproliferative activity was tested against HeLa (cervical carcinoma), SW620 (colorectal adenocarcinoma, metastatic), hepatocellular carcinoma (HEpG2), lung carcinoma cells (A549) and mouse embryo fibroblast cell line (3T3). The best antioxidant activity showed compound 2 with two hydroxy groups substituted on phenyl ring in positions 2' and 3'. The best antimicrobial activity of all synthesized compounds showed compound 8, while the best antiproliferative activity showed compound 6. Results signify the importance of xanthene-1,8-dione derivatives as potential antioxidant and antiproliferative agents. PB - Croatian Chemical Soc, Zagreb T2 - Croatica Chemica Acta T1 - Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives VL - 91 IS - 1 SP - 1 EP - 9 DO - 10.5562/cca3225 ER -
@article{ author = "Zukic, Selma and Veljović, Elma and Špirtović-Halilović, Selma and Muratovic, Samija and Osmanović, Amar and Trifunović, Snežana S. and Novaković, Irena T. and Završnik, Davorka", year = "2018", abstract = "Ten biologically active 2,2,5,5-tetramethy1-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives were synthesized and their structures were confirmed by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Synthesized compounds were scanned for their antioxidant, antimicrobial and antiproliferative activity. Antibacterial activity was tested by the diffusion and dilution method against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, while a ntifunga I activity was tested against Candida albicans and Saccharomyces cerevisiae. Antiproliferative activity was tested against HeLa (cervical carcinoma), SW620 (colorectal adenocarcinoma, metastatic), hepatocellular carcinoma (HEpG2), lung carcinoma cells (A549) and mouse embryo fibroblast cell line (3T3). The best antioxidant activity showed compound 2 with two hydroxy groups substituted on phenyl ring in positions 2' and 3'. The best antimicrobial activity of all synthesized compounds showed compound 8, while the best antiproliferative activity showed compound 6. Results signify the importance of xanthene-1,8-dione derivatives as potential antioxidant and antiproliferative agents.", publisher = "Croatian Chemical Soc, Zagreb", journal = "Croatica Chemica Acta", title = "Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives", volume = "91", number = "1", pages = "1-9", doi = "10.5562/cca3225" }
Zukic, S., Veljović, E., Špirtović-Halilović, S., Muratovic, S., Osmanović, A., Trifunović, S. S., Novaković, I. T.,& Završnik, D.. (2018). Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives. in Croatica Chemica Acta Croatian Chemical Soc, Zagreb., 91(1), 1-9. https://doi.org/10.5562/cca3225
Zukic S, Veljović E, Špirtović-Halilović S, Muratovic S, Osmanović A, Trifunović SS, Novaković IT, Završnik D. Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives. in Croatica Chemica Acta. 2018;91(1):1-9. doi:10.5562/cca3225 .
Zukic, Selma, Veljović, Elma, Špirtović-Halilović, Selma, Muratovic, Samija, Osmanović, Amar, Trifunović, Snežana S., Novaković, Irena T., Završnik, Davorka, "Antioxidant, Antimicrobial and Antiproliferative Activities of Synthesized 2,2,5,5-Tetramethyl-9-aryl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione Derivatives" in Croatica Chemica Acta, 91, no. 1 (2018):1-9, https://doi.org/10.5562/cca3225 . .