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Tween 80-solubilized Newcastle disease virus prepared as a water-in-oil-in-water vaccine
dc.creator | Cajavec, S | |
dc.creator | Bidin, Z | |
dc.creator | Sladić, Dušan | |
dc.creator | Pokric, B | |
dc.date.accessioned | 2018-11-22T00:01:09Z | |
dc.date.available | 2018-11-22T00:01:09Z | |
dc.date.issued | 1996 | |
dc.identifier.issn | 0005-2086 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/2240 | |
dc.description.abstract | The Newcastle disease virus (NDV) was solubilized with 10% w/v Tween 80 and inactivated with 0.05% v/v formalin. The average molecular mass of the released antigenic subunits was 307 kD. The rested vaccine was prepared in the form of a water-in-oil-in-water emulsion (WOWE) vaccine. The oil-to-aqueous ratio was 1:2. The solubilized NDV was administered alone or built in a tetravalent WOWE vaccine. A dose of the monovalent vaccine containing an equivalent of 44.7 mu l of detergent-treated NDV-allantoic fluid (NDV-AF) was sufficient for the complete protection of the commercially available chickens vaccinated at the age of 5 wk and challenged 7 wk later. The anti-NDV-free chickens, vaccinated at 4 wk of age and challenged 2 wk postvaccination, were 100% and 73% protected by a vaccinal dose containing 178.6 and 89.3 yl of detergent-treated NDV-AF, respectively. Commercially available light pullers, primary vaccinated with live lentogenic NDV vaccine, generated a protective level of NDV antibodies after revaccination with WOWE vaccine containing 89.3 mu l of detergent treated NDV-AF. Laying hens were revaccinated under field conditions at the beginning of the laying cycle by the terravalent vaccine. A vaccinal dose/bird containing 11.2 mu l of detergent-treated NDV-AF elicited a long-lasting high level of NDV neutralizing antibodies. | en |
dc.publisher | Amer Assoc Avian Pathologists, Athens | |
dc.rights | restrictedAccess | |
dc.source | Avian Diseases | |
dc.subject | chicken | en |
dc.subject | inactivated vaccine | en |
dc.subject | laying hens | en |
dc.subject | Newcastle disease virus | en |
dc.subject | polyvalent vaccine | en |
dc.subject | puller | en |
dc.subject | split-off vaccine | en |
dc.subject | water-in-oil-in-water vaccine | en |
dc.title | Tween 80-solubilized Newcastle disease virus prepared as a water-in-oil-in-water vaccine | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Покриц, Б; Сладић, Душан; Бидин, З; Цајавец, С; | |
dc.citation.volume | 40 | |
dc.citation.issue | 1 | |
dc.citation.spage | 193 | |
dc.citation.epage | 201 | |
dc.identifier.wos | A1996UC03800025 | |
dc.identifier.doi | 10.2307/1592389 | |
dc.citation.other | 40(1): 193-201 | |
dc.identifier.pmid | 8713034 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-0029691216 |
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