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dc.creatorPantić, Darko N.
dc.creatorAranđelović, Sandra
dc.creatorRadulović, Siniša
dc.creatorRoller, Alexander
dc.creatorArion, Vladimir B.
dc.creatorGrgurić-Šipka, Sanja
dc.date.accessioned2018-11-22T00:36:34Z
dc.date.available2018-11-22T00:36:34Z
dc.date.issued2016
dc.identifier.issn0022-328X
dc.identifier.urihttps://cherry.chem.bg.ac.rs/handle/123456789/2297
dc.description.abstractThree new ruthenium(II)-earene halido complexes of general formula [(eta(6-)p-cymene)RuX(L)] (C1-C3) were synthesised by reaction of [(eta(6)-p-cymene)RuX2](2) (X- = Cl-, Br-, I-) with 1H-benzimidazole-2-carboxylic acid (HL) in ethanol. The complexes were characterised by elemental analysis, mass spectrometry, IR, H-1 and C-13 NMR spectroscopy. The 1H-benzimidazole-2-carboxylate was found to act as a bidentate N,-Oechelating ligand. Single-crystal X-ray diffraction analysis confirmed the "piano-stool" geometry of C3. The cytotoxic activity of the ligand precursor and ruthenium complexes was tested in human cancer cell lines: cervical carcinoma (HeLa), breast carcinoma (MDA-MB-231), myelogenous leukemia (K562) as well as in one normal human fetal lung fibroblast cell line (MRC-5), by MTT assay. The results show that ruthenium(II)-arene complexes possess enhanced cytotoxicity when compared to that of HL. The latter was devoid of activity in the range of concentrations up to 300 mu M. Complex C3, carrying an iodido leaving ligand, exhibited moderate, but selective cytotoxicity toward HeLa, MDA-MB-231 and K562 cell lines, with IC50 values: 73.7, 60.9 and 53.9 mu M, respectively, being less toxic against MRC-5 cells (IC50 - 175.9 mu M). Complexes C1 and C2 showed moderate to low cytotoxicity in HeLa and K562 cells. (C) 2016 Elsevier B.V. All rights reserved.en
dc.publisherElsevier Science Sa, Lausanne
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/256716/EU//
dc.rightsrestrictedAccess
dc.sourceJournal of Organometallic Chemistry
dc.subjectRuthenium(II)-areneen
dc.subjectp-cymeneen
dc.subject1H-benzimidazole-2-carboxylic aciden
dc.subjectCytotoxic activityen
dc.titleSynthesis, characterisation and cytotoxic activity of organoruthenium(II)-halido complexes with 1H-benzimidazole-2-carboxylic aciden
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAрион, Владимир Б.; Aранделовиц, Сандра; Радуловиц, Синиса; Роллер, Aлеxандер; Пантиц, Дарко Н.; Гргурић-Шипка, Сања;
dc.citation.volume819
dc.citation.spage61
dc.citation.epage68
dc.identifier.wos000382199000008
dc.identifier.doi10.1016/j.jorganchem.2016.06.024
dc.citation.other819: 61-68
dc.citation.rankM22
dc.description.otherSupplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3633]
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-84975830696


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