Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney
Само за регистроване кориснике
2016
Аутори
Nikolić-Kokić, AleksandraMijušković, Ana
Tatalović, Nikola
Nestorov, Jelena
Miler, Marko
Oreščanin-Dušić, Zorana
Nikolić, Milan
Milošević, Verica
Blagojević, Duško P.
Spasić, Mihajlo B.
Miljević, Čedo
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The use of atypical antipsychotic drugs (APD) was reported to be associated with adverse effects on the kidneys. Thus, the aim of this study was to examine whether APD exerted their adverse effects by interfering with the renal antioxidant defense system. Male 3-mo-old Wistar rats were treated for 28 d with ziprasidone (ZIP), clozapine (CLO), or sertindole (SER) using a daily dose recommended for antipsychotic drug therapy. The expression and activities of antioxidant enzymes superoxide dismutase (SOD) type 1 and type 2, catalase (CAT), glutathione reductase (GR), and glutathione S-transferases (GSTs) activity were measured in the kidneys. Changes in the kidneys were also evaluated histologically. Ziprasidone, CLO, and SER reduced renal SOD type 1 and type 2 activities. Decreased CAT activity was observed only in SER-treated rats. An inhibition in GR activity and increased activity of GST was found only after treatment with CLO. Histological analysis showed dilatation of proximal tubul...es in kidneys with all three drugs. In conclusion, data indicate that redox disturbances may contribute to renal morphologic alterations in proximal tubules in rats treated with all APD.
Извор:
Journal of Toxicology and Environmental Health. Part A, 2016, 79, 20, 905-911Издавач:
- Taylor & Francis Inc, Philadelphia
Финансирање / пројекти:
- Молекуларни механизми редокс сигналинга у хомеостази, адаптацији и патологији (RS-MESTD-Basic Research (BR or ON)-173014)
DOI: 10.1080/15287394.2016.1201706
ISSN: 1528-7394
PubMed: 27644343
WoS: 000384551300003
Scopus: 2-s2.0-84988527274
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Nikolić-Kokić, Aleksandra AU - Mijušković, Ana AU - Tatalović, Nikola AU - Nestorov, Jelena AU - Miler, Marko AU - Oreščanin-Dušić, Zorana AU - Nikolić, Milan AU - Milošević, Verica AU - Blagojević, Duško P. AU - Spasić, Mihajlo B. AU - Miljević, Čedo PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2319 AB - The use of atypical antipsychotic drugs (APD) was reported to be associated with adverse effects on the kidneys. Thus, the aim of this study was to examine whether APD exerted their adverse effects by interfering with the renal antioxidant defense system. Male 3-mo-old Wistar rats were treated for 28 d with ziprasidone (ZIP), clozapine (CLO), or sertindole (SER) using a daily dose recommended for antipsychotic drug therapy. The expression and activities of antioxidant enzymes superoxide dismutase (SOD) type 1 and type 2, catalase (CAT), glutathione reductase (GR), and glutathione S-transferases (GSTs) activity were measured in the kidneys. Changes in the kidneys were also evaluated histologically. Ziprasidone, CLO, and SER reduced renal SOD type 1 and type 2 activities. Decreased CAT activity was observed only in SER-treated rats. An inhibition in GR activity and increased activity of GST was found only after treatment with CLO. Histological analysis showed dilatation of proximal tubules in kidneys with all three drugs. In conclusion, data indicate that redox disturbances may contribute to renal morphologic alterations in proximal tubules in rats treated with all APD. PB - Taylor & Francis Inc, Philadelphia T2 - Journal of Toxicology and Environmental Health. Part A T1 - Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney VL - 79 IS - 20 SP - 905 EP - 911 DO - 10.1080/15287394.2016.1201706 ER -
@article{ author = "Nikolić-Kokić, Aleksandra and Mijušković, Ana and Tatalović, Nikola and Nestorov, Jelena and Miler, Marko and Oreščanin-Dušić, Zorana and Nikolić, Milan and Milošević, Verica and Blagojević, Duško P. and Spasić, Mihajlo B. and Miljević, Čedo", year = "2016", abstract = "The use of atypical antipsychotic drugs (APD) was reported to be associated with adverse effects on the kidneys. Thus, the aim of this study was to examine whether APD exerted their adverse effects by interfering with the renal antioxidant defense system. Male 3-mo-old Wistar rats were treated for 28 d with ziprasidone (ZIP), clozapine (CLO), or sertindole (SER) using a daily dose recommended for antipsychotic drug therapy. The expression and activities of antioxidant enzymes superoxide dismutase (SOD) type 1 and type 2, catalase (CAT), glutathione reductase (GR), and glutathione S-transferases (GSTs) activity were measured in the kidneys. Changes in the kidneys were also evaluated histologically. Ziprasidone, CLO, and SER reduced renal SOD type 1 and type 2 activities. Decreased CAT activity was observed only in SER-treated rats. An inhibition in GR activity and increased activity of GST was found only after treatment with CLO. Histological analysis showed dilatation of proximal tubules in kidneys with all three drugs. In conclusion, data indicate that redox disturbances may contribute to renal morphologic alterations in proximal tubules in rats treated with all APD.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Journal of Toxicology and Environmental Health. Part A", title = "Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney", volume = "79", number = "20", pages = "905-911", doi = "10.1080/15287394.2016.1201706" }
Nikolić-Kokić, A., Mijušković, A., Tatalović, N., Nestorov, J., Miler, M., Oreščanin-Dušić, Z., Nikolić, M., Milošević, V., Blagojević, D. P., Spasić, M. B.,& Miljević, Č.. (2016). Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney. in Journal of Toxicology and Environmental Health. Part A Taylor & Francis Inc, Philadelphia., 79(20), 905-911. https://doi.org/10.1080/15287394.2016.1201706
Nikolić-Kokić A, Mijušković A, Tatalović N, Nestorov J, Miler M, Oreščanin-Dušić Z, Nikolić M, Milošević V, Blagojević DP, Spasić MB, Miljević Č. Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney. in Journal of Toxicology and Environmental Health. Part A. 2016;79(20):905-911. doi:10.1080/15287394.2016.1201706 .
Nikolić-Kokić, Aleksandra, Mijušković, Ana, Tatalović, Nikola, Nestorov, Jelena, Miler, Marko, Oreščanin-Dušić, Zorana, Nikolić, Milan, Milošević, Verica, Blagojević, Duško P., Spasić, Mihajlo B., Miljević, Čedo, "Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney" in Journal of Toxicology and Environmental Health. Part A, 79, no. 20 (2016):905-911, https://doi.org/10.1080/15287394.2016.1201706 . .