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dc.creatorŠovrc, Ľubomír
dc.creatorBorovska, Katarina
dc.creatorCinková, Kristína
dc.creatorStanković, Dalibor
dc.creatorPlanková, Alexandra
dc.date.accessioned2018-11-22T00:41:23Z
dc.date.available2018-11-22T00:41:23Z
dc.date.issued2017
dc.identifier.issn0013-4686
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/2540
dc.description.abstractAn innovative, rapid and simple electrochemical approach for the reliable quantification of cytostatic drug flutamide (FLU) in various matrices is herein proposed. This platform involves coupling of differential pulse (DPV) and square-wave voltammetry (SWV) with a boron-doped diamond (BDD) electrode as the working electrode and 0.1 M sulphuric acid as the supporting electrolyte. For the first time, the voltammetric profile of FLU was manifested by three irreversible and diffusion-controlled oxidation peaks at + 1.1 (P1), + 1.4 (P2) and + 1.9 V (P3). The analytical performance evaluation was assessed for all three peaks, using both pulse voltammetric techniques with the optimized operating parameters and the highest sensitivity of 1.76 nA/mu M was accomplished for P2 using DPV and 3.54 nA/mu M for P3 using SWV. The corresponding linear concentration ranges were found to be 0.99-42.9 and 4.8-35.5 mu M with the detection limits of 0.42 and 0.18 mu M, respectively. The repeatability varied, depending on the oxidation peaks of FLU, with the relative standard deviations in the range of 3.3-8.8% and 2.9-9.3% for DPV and SWV, respectively. The proposed electrochemical platform was successfully applied in the analysis of pharmaceutical formulations, spiked human urine and water samples with the significant mean recoveries. Using BDD electrode, the current work establishes an advanced, simple and rapid alternative platform to so far used toxic mercury-based electrodes and time demanding chemically modified electrodes in cytostatic sensing. Besides, BDD electrode represents a comfortable electrochemical sensor for routine analysis in pharmaceutical, clinical and environmental chemistry. (C) 2017 Elsevier Ltd. All rights reserved.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172030/RS//
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/621375/EU//
dc.relationGrant Agency of the Slovak Republic [1/0489/16]
dc.relationGrant scheme for Support of Young Researchers and Excellent Teams of Young Researchers
dc.rightsrestrictedAccess
dc.sourceElectrochimica Acta
dc.subjectcytostatic drug flutamideen
dc.subjectboron-doped diamond electrodeen
dc.subjectelectrochemical sensoren
dc.subjectdifferential pulse voltammetryen
dc.subjectsquare-wave voltammetryen
dc.titleAdvanced electrochemical platform for determination of cytostatic drug flutamide in various matrices using a boron-doped diamond electrodeen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСворц, Лубомир; Цинкова, Кристина; Станковић, Далибор; Боровска, Катарина; Планкова, Aлеxандра;
dc.citation.volume251
dc.citation.spage621
dc.citation.epage630
dc.identifier.wos000413004200067
dc.identifier.doi10.1016/j.electacta.2017.08.077
dc.citation.other251: 621-630
dc.citation.rankM21
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-85028691293
dc.identifier.rcubKon_3356


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