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dc.creatorKojadinovic, Milica
dc.creatorArsic, Aleksandra
dc.creatorPetovic-Oggiano, Gordana
dc.creatorGavrović-Jankulović, Marija
dc.creatorGlibetic, Marija
dc.creatorPopović, Milica
dc.date.accessioned2018-11-22T00:41:33Z
dc.date.available2018-11-22T00:41:33Z
dc.date.issued2017
dc.identifier.issn0963-7486
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/2551
dc.description.abstractUrolithins (UROs) are metabolites derived from ellagic acid (EA) and ellagitannins (ETs) by gut microbiota after consumption of different ETs. The health effects attributed to UROs are numerous and diverse, ranging from antimalarial properties to anticancer activities and regulation of gene expression. The aim of this work was at assessing the effect of URO-A; -B; -C; -D on the oxidative status of colon epithelium using as a model colorectal adenocarcinoma cell line (Caco-2). No significant cytotoxic effects of UROs was noted, with the applied treatments. Supplementation of cell growth medium with a mixture of UROs decreased the level of intracellular reactive oxygen species both after short- and long-term exposure. UROs also affected the activity of antioxidative enzymes within the cell, especially catalase.Conclusions: At concentrations reached in the lumen of the gut, UROs can exert beneficial effects on the cells by decreasing oxidative stress thus preventing the damage caused by reactive oxygen species.en
dc.publisherTaylor & Francis Ltd, Abingdon
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41030/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172049/RS//
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/312090/EU//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Food Sciences and Nutrition
dc.subjectEllagitanninsen
dc.subjectellagic aciden
dc.subjecturolithinsen
dc.subjectcolorectal adenocarcinomaen
dc.subjectoxidative stressen
dc.titleEffect of urolithins on oxidative stress of colorectal adenocarcinomacells-Caco-2en
dc.typearticle
dc.rights.licenseARR
dcterms.abstractГавровић-Јанкуловић, Марија; Глибетиц, Марија; Aрсиц, Aлександра; Којадиновиц, Милица; Петовиц-Оггиано, Гордана; Поповић, Милица;
dc.citation.volume68
dc.citation.issue8
dc.citation.spage952
dc.citation.epage959
dc.identifier.wos000414916800007
dc.identifier.doi10.1080/09637486.2017.1328665
dc.citation.other68(8): 952-959
dc.citation.rankM22
dc.identifier.pmid28535698
dc.identifier.scopus2-s2.0-85019546603
dc.identifier.rcubKon_3367


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