Platinum and ruthenium complexes as promising molecules in cancer therapy
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Cancer is one of the most common fatal diseases in humans nowadays. About 20 million new cancer cases are expected in the next two decades worldwide. The development of new chemotherapeutic agents with improved properties is presently the main challenge in the medicinal chemistry. Cisplatin was introduced to oncology in 1978 as first chemotherapeutic agent regarding its specific interaction with DNA, leading to its damage and causing the cell death. Since the first application of cisplatin in cancer therapy, there has been a growing interest in new metal-based compounds, in particular platinum and ruthenium complexes, with better anticancer activity and less side-effects compared to cisplatin. Carboplatin and oxaliplatin have shown promising action against some types of cancer, which are resistant to cisplatin. With the aim to overcome cross-resistance to these Pt(II) drugs, bioavailable platinum complexes (satraplatin and picoplatin) firstly found application as orally administered dr...ugs, as well as some combined therapies of Pt(II) drugs (cisplatin, picoplatin) with specific resistant modulators. In recent years, novel polymer and liposomal formulations of platinum drugs (prolindac, lipoplatin, lipoxal, aroplatin) have been designed with strategy to improve drug delivery to target cancer cells and reduce toxicity. Complexes based on ruthenium have great potential to become leading candidates for the medical use in anticancer therapy. Some of these compounds have shown good anticancer activity, both in vitro and in vivo and two of them (KP1019 and NAMI-A) have passed clinical trials and given promising results.
Кључне речи:
Anticancer activity / Cancer therapy / Metal complexes / Platinum / RutheniumИзвор:
Srpski Arhiv za Celokupno Lekarstvo, 2019, 147, 1-2, 105-109Издавач:
- Srpsko lekarsko društvo
Финансирање / пројекти:
- Истраживања интеракција ензима са токсичним и фармаколошки активним молекулима (RS-172023)
- Развој нових инкапсулационих и ензимских технологија за производњу биокатализатора и биолошки активних компонената хране у циљу повећања њене конкурентности, квалитета и безбедности (RS-46010)
- Рационални дизајн и синтеза биолошки активних и координационих једињења и функционалних материјала, релевантних у (био)нанотехнологији (RS-172035)
DOI: 10.2298/SARH180706075A
ISSN: 0370-8179
WoS: 000463287200019
Scopus: 2-s2.0-85070026342
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Avramović, Nataša AU - Ignjatović, Nikola AU - Savić, Aleksandar PY - 2019 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3304 AB - Cancer is one of the most common fatal diseases in humans nowadays. About 20 million new cancer cases are expected in the next two decades worldwide. The development of new chemotherapeutic agents with improved properties is presently the main challenge in the medicinal chemistry. Cisplatin was introduced to oncology in 1978 as first chemotherapeutic agent regarding its specific interaction with DNA, leading to its damage and causing the cell death. Since the first application of cisplatin in cancer therapy, there has been a growing interest in new metal-based compounds, in particular platinum and ruthenium complexes, with better anticancer activity and less side-effects compared to cisplatin. Carboplatin and oxaliplatin have shown promising action against some types of cancer, which are resistant to cisplatin. With the aim to overcome cross-resistance to these Pt(II) drugs, bioavailable platinum complexes (satraplatin and picoplatin) firstly found application as orally administered drugs, as well as some combined therapies of Pt(II) drugs (cisplatin, picoplatin) with specific resistant modulators. In recent years, novel polymer and liposomal formulations of platinum drugs (prolindac, lipoplatin, lipoxal, aroplatin) have been designed with strategy to improve drug delivery to target cancer cells and reduce toxicity. Complexes based on ruthenium have great potential to become leading candidates for the medical use in anticancer therapy. Some of these compounds have shown good anticancer activity, both in vitro and in vivo and two of them (KP1019 and NAMI-A) have passed clinical trials and given promising results. PB - Srpsko lekarsko društvo T2 - Srpski Arhiv za Celokupno Lekarstvo T1 - Platinum and ruthenium complexes as promising molecules in cancer therapy VL - 147 IS - 1-2 SP - 105 EP - 109 DO - 10.2298/SARH180706075A ER -
@article{ author = "Avramović, Nataša and Ignjatović, Nikola and Savić, Aleksandar", year = "2019", abstract = "Cancer is one of the most common fatal diseases in humans nowadays. About 20 million new cancer cases are expected in the next two decades worldwide. The development of new chemotherapeutic agents with improved properties is presently the main challenge in the medicinal chemistry. Cisplatin was introduced to oncology in 1978 as first chemotherapeutic agent regarding its specific interaction with DNA, leading to its damage and causing the cell death. Since the first application of cisplatin in cancer therapy, there has been a growing interest in new metal-based compounds, in particular platinum and ruthenium complexes, with better anticancer activity and less side-effects compared to cisplatin. Carboplatin and oxaliplatin have shown promising action against some types of cancer, which are resistant to cisplatin. With the aim to overcome cross-resistance to these Pt(II) drugs, bioavailable platinum complexes (satraplatin and picoplatin) firstly found application as orally administered drugs, as well as some combined therapies of Pt(II) drugs (cisplatin, picoplatin) with specific resistant modulators. In recent years, novel polymer and liposomal formulations of platinum drugs (prolindac, lipoplatin, lipoxal, aroplatin) have been designed with strategy to improve drug delivery to target cancer cells and reduce toxicity. Complexes based on ruthenium have great potential to become leading candidates for the medical use in anticancer therapy. Some of these compounds have shown good anticancer activity, both in vitro and in vivo and two of them (KP1019 and NAMI-A) have passed clinical trials and given promising results.", publisher = "Srpsko lekarsko društvo", journal = "Srpski Arhiv za Celokupno Lekarstvo", title = "Platinum and ruthenium complexes as promising molecules in cancer therapy", volume = "147", number = "1-2", pages = "105-109", doi = "10.2298/SARH180706075A" }
Avramović, N., Ignjatović, N.,& Savić, A.. (2019). Platinum and ruthenium complexes as promising molecules in cancer therapy. in Srpski Arhiv za Celokupno Lekarstvo Srpsko lekarsko društvo., 147(1-2), 105-109. https://doi.org/10.2298/SARH180706075A
Avramović N, Ignjatović N, Savić A. Platinum and ruthenium complexes as promising molecules in cancer therapy. in Srpski Arhiv za Celokupno Lekarstvo. 2019;147(1-2):105-109. doi:10.2298/SARH180706075A .
Avramović, Nataša, Ignjatović, Nikola, Savić, Aleksandar, "Platinum and ruthenium complexes as promising molecules in cancer therapy" in Srpski Arhiv za Celokupno Lekarstvo, 147, no. 1-2 (2019):105-109, https://doi.org/10.2298/SARH180706075A . .