Cytokinesis block micronucleus assay in human lymphocytes after exposure to Ru(III) thiosemicarbazone complexes in vitro
Само за регистроване кориснике
2018
Аутори
Ljubijankić, NevzetaStanković, Miomir
Tešević, Vele
Grgurić-Šipka, Sanja
Jadranin, Milka
Begić, Sabina
Šabanović, Elma
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
This study evaluates the genotoxic potential of two Ru(III) complexes with thiosemicarbazone based ligands. The complexes were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using the cytokinesis block micronucleus (CBMN) assay at concentrations 1.5; 3.7 and 7.4 μg/mL. The cell culture treated with the tested complexes, at 3.7 μg/mL concentration, decreased a frequency of micronucleus for 37% and 32%, when compared with the control cell cultures. At concentration of 7.4 (1.5) μg/mL of this complexes exhibited slightly lower effect of micronucleus for 30% (35%) and 27% (29%), when compared with the control cell cultures. © RASĀYAN. All rights reserved.
Кључне речи:
CBMN assay / Chromosome aberrations / Genotoxicity / Micronucleus / Ruthenium(III) complexes / ThiosemycarbazoneИзвор:
Rasayan Journal of Chemistry, 2018, 11, 2, 647-652Финансирање / пројекти:
- Federal Ministry of Education and Science, Bosnia and Herzegovina, Project No. 05-39-3087-21/16.
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Ljubijankić, Nevzeta AU - Stanković, Miomir AU - Tešević, Vele AU - Grgurić-Šipka, Sanja AU - Jadranin, Milka AU - Begić, Sabina AU - Šabanović, Elma PY - 2018 UR - https://cherry.chem.bg.ac.rs/handle/123456789/332 AB - This study evaluates the genotoxic potential of two Ru(III) complexes with thiosemicarbazone based ligands. The complexes were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using the cytokinesis block micronucleus (CBMN) assay at concentrations 1.5; 3.7 and 7.4 μg/mL. The cell culture treated with the tested complexes, at 3.7 μg/mL concentration, decreased a frequency of micronucleus for 37% and 32%, when compared with the control cell cultures. At concentration of 7.4 (1.5) μg/mL of this complexes exhibited slightly lower effect of micronucleus for 30% (35%) and 27% (29%), when compared with the control cell cultures. © RASĀYAN. All rights reserved. T2 - Rasayan Journal of Chemistry T1 - Cytokinesis block micronucleus assay in human lymphocytes after exposure to Ru(III) thiosemicarbazone complexes in vitro VL - 11 IS - 2 SP - 647 EP - 652 DO - 10.31788/rjc.2018.1123004 ER -
@article{ author = "Ljubijankić, Nevzeta and Stanković, Miomir and Tešević, Vele and Grgurić-Šipka, Sanja and Jadranin, Milka and Begić, Sabina and Šabanović, Elma", year = "2018", abstract = "This study evaluates the genotoxic potential of two Ru(III) complexes with thiosemicarbazone based ligands. The complexes were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using the cytokinesis block micronucleus (CBMN) assay at concentrations 1.5; 3.7 and 7.4 μg/mL. The cell culture treated with the tested complexes, at 3.7 μg/mL concentration, decreased a frequency of micronucleus for 37% and 32%, when compared with the control cell cultures. At concentration of 7.4 (1.5) μg/mL of this complexes exhibited slightly lower effect of micronucleus for 30% (35%) and 27% (29%), when compared with the control cell cultures. © RASĀYAN. All rights reserved.", journal = "Rasayan Journal of Chemistry", title = "Cytokinesis block micronucleus assay in human lymphocytes after exposure to Ru(III) thiosemicarbazone complexes in vitro", volume = "11", number = "2", pages = "647-652", doi = "10.31788/rjc.2018.1123004" }
Ljubijankić, N., Stanković, M., Tešević, V., Grgurić-Šipka, S., Jadranin, M., Begić, S.,& Šabanović, E.. (2018). Cytokinesis block micronucleus assay in human lymphocytes after exposure to Ru(III) thiosemicarbazone complexes in vitro. in Rasayan Journal of Chemistry, 11(2), 647-652. https://doi.org/10.31788/rjc.2018.1123004
Ljubijankić N, Stanković M, Tešević V, Grgurić-Šipka S, Jadranin M, Begić S, Šabanović E. Cytokinesis block micronucleus assay in human lymphocytes after exposure to Ru(III) thiosemicarbazone complexes in vitro. in Rasayan Journal of Chemistry. 2018;11(2):647-652. doi:10.31788/rjc.2018.1123004 .
Ljubijankić, Nevzeta, Stanković, Miomir, Tešević, Vele, Grgurić-Šipka, Sanja, Jadranin, Milka, Begić, Sabina, Šabanović, Elma, "Cytokinesis block micronucleus assay in human lymphocytes after exposure to Ru(III) thiosemicarbazone complexes in vitro" in Rasayan Journal of Chemistry, 11, no. 2 (2018):647-652, https://doi.org/10.31788/rjc.2018.1123004 . .