Synthesis, Characterization and Biological Study of New Dinuclear Zinc(ii) and Nickel(ii) Octaaza Macrocyclic Complexes
Само за регистроване кориснике
2019
Аутори
Krstić, Milena P.Petković, Branka B.
Milčić, Miloš K.
Mišić, Dušan R.
Francisco Santibanez, Juan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative ...activity toward cancer cells MCF-7 and MDA-MB-231.
Кључне речи:
binding / biological activity / cations / cobalt(ii) / complex / copper(ii) complexes / crystal-structure / cu(ii) / cyclam / in-vitro / ligand / nickel / stability / tpmc / zincИзвор:
Macedonian Journal of Chemistry and Chemical Engineering, 2019, 38, 1, 1-11Издавач:
- SOC CHEMISTS TECHNOLOGISTS MADECONIA
Финансирање / пројекти:
- Дизајнирање, синтеза, карактеризација и процена практичне примене координационих и органометалних једињења (RS-172014)
- Вишескално структурирање полимерних нанокомпозита и функционалних материјала применом различитих прекурсора (RS-45022)
- Испитивање патогенезе хематолошких малигнитета (RS-175053)
DOI: 10.20450/mjcce.2019.1599
ISSN: 1857-5552
WoS: 000477950400002
Scopus: 2-s2.0-85070517101
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Krstić, Milena P. AU - Petković, Branka B. AU - Milčić, Miloš K. AU - Mišić, Dušan R. AU - Francisco Santibanez, Juan PY - 2019 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3689 AB - Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231. PB - SOC CHEMISTS TECHNOLOGISTS MADECONIA T2 - Macedonian Journal of Chemistry and Chemical Engineering T1 - Synthesis, Characterization and Biological Study of New Dinuclear Zinc(ii) and Nickel(ii) Octaaza Macrocyclic Complexes VL - 38 IS - 1 SP - 1 EP - 11 DO - 10.20450/mjcce.2019.1599 ER -
@article{ author = "Krstić, Milena P. and Petković, Branka B. and Milčić, Miloš K. and Mišić, Dušan R. and Francisco Santibanez, Juan", year = "2019", abstract = "Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231.", publisher = "SOC CHEMISTS TECHNOLOGISTS MADECONIA", journal = "Macedonian Journal of Chemistry and Chemical Engineering", title = "Synthesis, Characterization and Biological Study of New Dinuclear Zinc(ii) and Nickel(ii) Octaaza Macrocyclic Complexes", volume = "38", number = "1", pages = "1-11", doi = "10.20450/mjcce.2019.1599" }
Krstić, M. P., Petković, B. B., Milčić, M. K., Mišić, D. R.,& Francisco Santibanez, J.. (2019). Synthesis, Characterization and Biological Study of New Dinuclear Zinc(ii) and Nickel(ii) Octaaza Macrocyclic Complexes. in Macedonian Journal of Chemistry and Chemical Engineering SOC CHEMISTS TECHNOLOGISTS MADECONIA., 38(1), 1-11. https://doi.org/10.20450/mjcce.2019.1599
Krstić MP, Petković BB, Milčić MK, Mišić DR, Francisco Santibanez J. Synthesis, Characterization and Biological Study of New Dinuclear Zinc(ii) and Nickel(ii) Octaaza Macrocyclic Complexes. in Macedonian Journal of Chemistry and Chemical Engineering. 2019;38(1):1-11. doi:10.20450/mjcce.2019.1599 .
Krstić, Milena P., Petković, Branka B., Milčić, Miloš K., Mišić, Dušan R., Francisco Santibanez, Juan, "Synthesis, Characterization and Biological Study of New Dinuclear Zinc(ii) and Nickel(ii) Octaaza Macrocyclic Complexes" in Macedonian Journal of Chemistry and Chemical Engineering, 38, no. 1 (2019):1-11, https://doi.org/10.20450/mjcce.2019.1599 . .