Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes
Апстракт
The activity of the isoenzymes of N-acetyl-beta-D-glucosaminidase (NAG, EC 3.2.1.30) is determined in the serum of insulin-dependent (IDDM) and non insulin-dependent diabetics (NIDDM) with or without diabetic complications. The increase in total activity of serum NAG in diabetics is proportional to the A form activity (r=0,976, p lt 0,0001). The contribution of the A form activity (65.87+/-5.99%) to total NAG activity of IDDM and NIDDM diabetics with and without complications does not change considerably compared to the control group. The contribution of the B form activity depends on the state of metabolic monitoring and diabetic complications. A significantly lower activity of the serum B form was found in IDDM (p lt 0,001) and NIDDM diabetics (p lt 0,05) compared to the healthy individuals, as well as the higher activity ratios of the A/B forms. A decrease in serum B form is correlated with the occurrence and abundance of the intermediary I forms (r=-0,665). These changes are parti...cularly significant in the individuals with the pronounced microangiopathy.
Кључне речи:
N-acetyl-beta-D-glucosaminidase / isoenzymes / isoenzyme activity ratio A/B / insulin-dependent and non-insulin-dependent diabetes / diabetic complicationsИзвор:
Biochemistry and Molecular Biology International, 1998, 45, 3, 545-554Издавач:
- Academic Press Aust, Marrickville
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Mandić, Ljuba M. AU - Filipović, Dragana PY - 1998 UR - https://cherry.chem.bg.ac.rs/handle/123456789/382 AB - The activity of the isoenzymes of N-acetyl-beta-D-glucosaminidase (NAG, EC 3.2.1.30) is determined in the serum of insulin-dependent (IDDM) and non insulin-dependent diabetics (NIDDM) with or without diabetic complications. The increase in total activity of serum NAG in diabetics is proportional to the A form activity (r=0,976, p lt 0,0001). The contribution of the A form activity (65.87+/-5.99%) to total NAG activity of IDDM and NIDDM diabetics with and without complications does not change considerably compared to the control group. The contribution of the B form activity depends on the state of metabolic monitoring and diabetic complications. A significantly lower activity of the serum B form was found in IDDM (p lt 0,001) and NIDDM diabetics (p lt 0,05) compared to the healthy individuals, as well as the higher activity ratios of the A/B forms. A decrease in serum B form is correlated with the occurrence and abundance of the intermediary I forms (r=-0,665). These changes are particularly significant in the individuals with the pronounced microangiopathy. PB - Academic Press Aust, Marrickville T2 - Biochemistry and Molecular Biology International T1 - Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes VL - 45 IS - 3 SP - 545 EP - 554 UR - https://hdl.handle.net/21.15107/rcub_cherry_382 ER -
@article{ author = "Mandić, Ljuba M. and Filipović, Dragana", year = "1998", abstract = "The activity of the isoenzymes of N-acetyl-beta-D-glucosaminidase (NAG, EC 3.2.1.30) is determined in the serum of insulin-dependent (IDDM) and non insulin-dependent diabetics (NIDDM) with or without diabetic complications. The increase in total activity of serum NAG in diabetics is proportional to the A form activity (r=0,976, p lt 0,0001). The contribution of the A form activity (65.87+/-5.99%) to total NAG activity of IDDM and NIDDM diabetics with and without complications does not change considerably compared to the control group. The contribution of the B form activity depends on the state of metabolic monitoring and diabetic complications. A significantly lower activity of the serum B form was found in IDDM (p lt 0,001) and NIDDM diabetics (p lt 0,05) compared to the healthy individuals, as well as the higher activity ratios of the A/B forms. A decrease in serum B form is correlated with the occurrence and abundance of the intermediary I forms (r=-0,665). These changes are particularly significant in the individuals with the pronounced microangiopathy.", publisher = "Academic Press Aust, Marrickville", journal = "Biochemistry and Molecular Biology International", title = "Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes", volume = "45", number = "3", pages = "545-554", url = "https://hdl.handle.net/21.15107/rcub_cherry_382" }
Mandić, L. M.,& Filipović, D.. (1998). Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes. in Biochemistry and Molecular Biology International Academic Press Aust, Marrickville., 45(3), 545-554. https://hdl.handle.net/21.15107/rcub_cherry_382
Mandić LM, Filipović D. Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes. in Biochemistry and Molecular Biology International. 1998;45(3):545-554. https://hdl.handle.net/21.15107/rcub_cherry_382 .
Mandić, Ljuba M., Filipović, Dragana, "Changes of isoenzymes of serum N-acetyl-beta-glucosaminidase in relation to different types of diabetes" in Biochemistry and Molecular Biology International, 45, no. 3 (1998):545-554, https://hdl.handle.net/21.15107/rcub_cherry_382 .