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Halophytic plant species - isolation and characterization of secondary metabolites

dc.contributor.advisorTešević, Vele
dc.contributor.otherNovaković, Miroslav M.
dc.contributor.otherGođevac, Dejan
dc.contributor.otherVujisić, Ljubodrag V.
dc.contributor.otherDajić-Stevanović, Zora
dc.creatorStanković, Jovana
dc.date.accessioned2020-04-01T18:44:52Z
dc.date.available2020-04-01T18:44:52Z
dc.date.issued2019
dc.identifier.urihttp://eteze.bg.ac.rs/application/showtheses?thesesId=7015
dc.identifier.urihttps://fedorabg.bg.ac.rs/fedora/get/o:20623/bdef:Content/download
dc.identifier.urihttp://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=51738383
dc.identifier.urihttp://nardus.mpn.gov.rs/123456789/11672
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/3909
dc.description.abstractPredmet proučavanja ove doktorske disertacije su sekundarni metaboliti halofita(biljaka koje naseljavaju staništa sa visokim sadržajem soli). U Srbiji se zaslanjenastaništa uglavnom javljaju na teritoriji Vojvodine. U ovom radu izolovani su i hemijskiokarakterisani flavonoidni glikozidi i saponini iz halofitnih vrsta roda Atriplex (A.littoralis, A. tatarica i A. prostrata) i određena je njihova različita biološka aktivnost.Pored biljaka iz roda Atriplex ispitivana je halofitna biljna vrsta Artemisia santonicum izkoje je izolovano etarsko ulje, određen hemijski sastav i ispitana biološka aktivnost.Halofitne biljne vrste se u tradicionalnoj medicini koriste u brojne svrhe kaoantiseptici, diuretici, antiparazitici, antipiretici, purgativi, laksativi, za lečenjedijabetesa, visokog krvnog pritiska, astme, gihta i reumatizma. Ekstrakti i jedinjenjaizolovana iz vrsta roda Atriplex pokazuju antioksidativnu, antimikrobnu, citotoksičnu,antiparazitsku, i insekticidnu aktivnost. Etarska ulja vrsta roda Artemisia su pokazalaantioksidativnu, antibakterijsku, antifungalnu, antiparazitsku, hepatoprotektivnu,neuroprotektivnu i antimalarijsku aktivnost.Vrste roda Atriplex su bogat izvor sekundarnih metabolita prvenstvenoflavonoida, saponina i alkaloida. U okviru ove disertacije izolovano je i okarakterisanoukupno 13 jedinjenja, od kojih je 7 novih prirodnih proizvoda (43-45, 51-54). Iz vrste A.littoralis izolovano je 6 jedinjenja, četiri flavonoidna glikozida (43-46) i dva fenolnajedinjenja (47, 48). Iz A. tatarica izolovano je 6 jedinjenja, tri flavonoidna glikozida(49-51) i tri triterpenska saponina oleanolnog tipa (52-54). Iz etarskog ulja Artemisiasantonicum izolovan je oksigenovani monoterpen (55)...sr
dc.description.abstractThe subject of this doctoral dissertation are the secondary metabolites ofhalophytes (plants wild growing at saline habitats). In Serbia such habitats are mainlyfound in Vojvodina. Flavonoid glycosides and saponins from halophytic speciesAtriplex (A. littoralis, A. tatarica and A. prostrata) were isolated, chemicallycharacterized and their various biological activities were determined. In addition, ahalophyte species from the genus Artemisia (A. santonicum) was examined. Its essentialoil was isolated, the chemical composition determined and various biological activitiesof this were tested.Several halophytic plant species are used in many traditional formulations asantiseptics, diuretics, antiparasitics, antipyretics, purgatives, laxatives, for the treatmentof diabetes, high blood pressure, asthma, gout and rheumatism. Extracts and compoundsisolated from the genus Atriplex show antiparasitic, insecticidal, antimicrobial,cytotoxic and antioxidant activity. Essential oils of the genus Artemisia have shownantioxidant, antibacterial, antifungal, antiparasitic, hepatoprotective, neuroprotectiveand antimalarial activity.Atriplex species are a rich source of secondary metabolites, primarily flavonoids,saponins and alkaloids. In this study, a total of 13 compounds were isolated andcharacterized by means of spectroscopic techniques (1D and 2D NMR, IR and MS).Among them seven (43-45, 51-54) were the new compounds. At the same time, in theextract of A. littoralis, six compounds, four flavonoid glycosides (43-46) and twophenolic compounds (47, 48) were identified. From A. tatarica six compounds, threeflavonoid glycosides (49-51) and three triterpene saponins of an oleanane type (52-54)were isolated. An oxygenated monoterpene (55) was isolated from Artemisiasantonicum essential oil...en
dc.formatapplication/pdf
dc.languagesr
dc.publisherУниверзитет у Београду, Хемијски факултетsr
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.rightsopenAccess
dc.sourceУниверзитет у Београдуsr
dc.subjectHalofitesr
dc.subjecthalophytesen
dc.subjectAtriplexsr
dc.subjectArtemisiasr
dc.subjectflavonoidni glikozidisr
dc.subjectsaponinisr
dc.subjectDNK protektivna aktivnostsr
dc.subjectantibakterijskasr
dc.subjectantifungalnasr
dc.subjectanti-quorum sensingaktivnostsr
dc.subjectAtriplexen
dc.subjectArtemisiaen
dc.subjectflavonoid glycosidesen
dc.subjectsaponinsen
dc.subjectDNA protective activityen
dc.subjectantibacterialen
dc.subjectantifungalen
dc.subjectanti-quorum sensing activityen
dc.titleHalofitne biljne vrste - izolovanje i karakterizacija sekundarnih metabolitasr
dc.title.alternativeHalophytic plant species - isolation and characterization of secondary metabolitesen
dc.typedoctoralThesisen
dc.rights.licenseBY-NC-ND
dcterms.abstractТешевић, Веле; Новаковић, Мирослав; Вујисић, Љубодраг; Дајић-Стевановић, Зора; Гођевац, Дејан; Станковић, Јована; Халофитне биљне врсте - изоловање и карактеризација секундарних метаболита; Халофитне биљне врсте - изоловање и карактеризација секундарних метаболита;
dc.type.versionpublishedVersionen
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/16896/Disertacija.pdf
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/16897/IzvestajKomisije21234.pdf


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