Nitric Oxide and its Role in Cardiovascular Diseases
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Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation. NO is a free radical which reacts with various molecules to cause multiple biological effects. It is clear that the generation and actions of NO under physiological and pathophysiological conditions are exquisitely regulated and extend to almost every cell type and function within the circulation. While the molecule mediates many physiological functions, an excessive presence of NO is toxic to cells. The enzyme NOS, constitutively or inductively, catalyses the production of NO in several biological systems. NO is derived not only from NOS isoforms but also from NOS-independent sources. In mammals, to date, three distinct NOS isoforms have been identified: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). The molecular structure, enzymology and pharmacology of these enzymes have been well defined, and reveal critical roles for the NOS system in a variety of important physiolog...ical processes. This review focuses on recent advances in the understanding of the interactions between NOS enzymes and pathophysiology of cardiovascular diseases (CVD) and the role of NO agonists as potential therapeutic agents in treatment of CVD.
Кључне речи:
nitric oxide / nitric oxide synthase / endothelial dysfunction / chronic heart failureИзвор:
The Open Nitric Oxide Journal, 2011, 3, 1, 65-71Издавач:
- Bentham Open
Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-MESTD-Basic Research (BR or ON)-173033)
- DAAD Grant founded by Deutscher Akademischer Austauschdienst- No. A/11/04833 ( to E.R. I and H. D).
Напомена:
- The Open Nitric oxide Journal has been discontinued.
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Dobutović, Branislava AU - Smiljanić, Katarina AU - Soskić, Sanja AU - Dungen, Hans-Dirk AU - Isenović, Esma PY - 2011 UR - https://cherry.chem.bg.ac.rs/handle/123456789/3918 AB - Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation. NO is a free radical which reacts with various molecules to cause multiple biological effects. It is clear that the generation and actions of NO under physiological and pathophysiological conditions are exquisitely regulated and extend to almost every cell type and function within the circulation. While the molecule mediates many physiological functions, an excessive presence of NO is toxic to cells. The enzyme NOS, constitutively or inductively, catalyses the production of NO in several biological systems. NO is derived not only from NOS isoforms but also from NOS-independent sources. In mammals, to date, three distinct NOS isoforms have been identified: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). The molecular structure, enzymology and pharmacology of these enzymes have been well defined, and reveal critical roles for the NOS system in a variety of important physiological processes. This review focuses on recent advances in the understanding of the interactions between NOS enzymes and pathophysiology of cardiovascular diseases (CVD) and the role of NO agonists as potential therapeutic agents in treatment of CVD. PB - Bentham Open T2 - The Open Nitric Oxide Journal T1 - Nitric Oxide and its Role in Cardiovascular Diseases VL - 3 IS - 1 SP - 65 EP - 71 DO - 10.2174/1875042701103010065 ER -
@article{ author = "Dobutović, Branislava and Smiljanić, Katarina and Soskić, Sanja and Dungen, Hans-Dirk and Isenović, Esma", year = "2011", abstract = "Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation. NO is a free radical which reacts with various molecules to cause multiple biological effects. It is clear that the generation and actions of NO under physiological and pathophysiological conditions are exquisitely regulated and extend to almost every cell type and function within the circulation. While the molecule mediates many physiological functions, an excessive presence of NO is toxic to cells. The enzyme NOS, constitutively or inductively, catalyses the production of NO in several biological systems. NO is derived not only from NOS isoforms but also from NOS-independent sources. In mammals, to date, three distinct NOS isoforms have been identified: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). The molecular structure, enzymology and pharmacology of these enzymes have been well defined, and reveal critical roles for the NOS system in a variety of important physiological processes. This review focuses on recent advances in the understanding of the interactions between NOS enzymes and pathophysiology of cardiovascular diseases (CVD) and the role of NO agonists as potential therapeutic agents in treatment of CVD.", publisher = "Bentham Open", journal = "The Open Nitric Oxide Journal", title = "Nitric Oxide and its Role in Cardiovascular Diseases", volume = "3", number = "1", pages = "65-71", doi = "10.2174/1875042701103010065" }
Dobutović, B., Smiljanić, K., Soskić, S., Dungen, H.,& Isenović, E.. (2011). Nitric Oxide and its Role in Cardiovascular Diseases. in The Open Nitric Oxide Journal Bentham Open., 3(1), 65-71. https://doi.org/10.2174/1875042701103010065
Dobutović B, Smiljanić K, Soskić S, Dungen H, Isenović E. Nitric Oxide and its Role in Cardiovascular Diseases. in The Open Nitric Oxide Journal. 2011;3(1):65-71. doi:10.2174/1875042701103010065 .
Dobutović, Branislava, Smiljanić, Katarina, Soskić, Sanja, Dungen, Hans-Dirk, Isenović, Esma, "Nitric Oxide and its Role in Cardiovascular Diseases" in The Open Nitric Oxide Journal, 3, no. 1 (2011):65-71, https://doi.org/10.2174/1875042701103010065 . .