Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars
Само за регистроване кориснике
2020
Аутори
Stikić, Radmila I.Milinčić, Danijel D.
Kostić, Aleksandar Ž.
Jovanović, Zorica
Gašić, Uroš M.
Tešić, Živoslav Lj.
Djordjević, Nataša Z.
Savić, Slađana K.
Czekus, Borisz G.
Pešić, Mirjana B.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background and objectives: Quinoa is considered to be a “natural functional food” due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health-promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings: Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time-dependent effects were more expressed in Puno extracts. Conclusions: The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human co...lorectal cancer was expressed in both investigated cultivars. Significance and novelty: The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT-116, as well as the presence of 7 new phenolic and flavonoid compounds.
Кључне речи:
antioxidant activity / colon cancer / cytotoxic activity / flavonoids / phenolic acids / quinoa seedИзвор:
Cereal Chemistry, 2020, 97, 3, 626-633Издавач:
- Wiley-Blackwell
Финансирање / пројекти:
- Савремени биотехнолошки приступ решавања проблема суше у пољопривреди Србије (RS-31005)
- Испитивање могућности коришћења контаминираних вода за гајење алтернативних, здравствено безбедних жита (RS-31006)
- Коришћење биљних извора протеина, дијеталних влакана и антиоксиданаса у производњи хране (RS-31069)
- Корелација структуре и особина природних и синтетичких молекула и њихових комплекса са металима (RS-172017)
- Физиолошка, хемијска и молекуларна анализа диверзитета одабраних ретких и угрожених биљних врста у циљу еx ситу заштите и продукције биолошки активних једињења (RS-173024)
- Молекуларно физиолошки биомониторинг аеробних организама заснован на одређивању биохемијских биомаркера оксидационог стреса (RS-173041)
DOI: 10.1002/cche.10278
ISSN: 0009-0352
WoS: 000521447000001
Scopus: 2-s2.0-85082187869
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Stikić, Radmila I. AU - Milinčić, Danijel D. AU - Kostić, Aleksandar Ž. AU - Jovanović, Zorica AU - Gašić, Uroš M. AU - Tešić, Živoslav Lj. AU - Djordjević, Nataša Z. AU - Savić, Slađana K. AU - Czekus, Borisz G. AU - Pešić, Mirjana B. PY - 2020 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4047 AB - Background and objectives: Quinoa is considered to be a “natural functional food” due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health-promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings: Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time-dependent effects were more expressed in Puno extracts. Conclusions: The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty: The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT-116, as well as the presence of 7 new phenolic and flavonoid compounds. PB - Wiley-Blackwell T2 - Cereal Chemistry T1 - Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars VL - 97 IS - 3 SP - 626 EP - 633 DO - 10.1002/cche.10278 ER -
@article{ author = "Stikić, Radmila I. and Milinčić, Danijel D. and Kostić, Aleksandar Ž. and Jovanović, Zorica and Gašić, Uroš M. and Tešić, Živoslav Lj. and Djordjević, Nataša Z. and Savić, Slađana K. and Czekus, Borisz G. and Pešić, Mirjana B.", year = "2020", abstract = "Background and objectives: Quinoa is considered to be a “natural functional food” due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health-promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings: Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time-dependent effects were more expressed in Puno extracts. Conclusions: The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty: The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT-116, as well as the presence of 7 new phenolic and flavonoid compounds.", publisher = "Wiley-Blackwell", journal = "Cereal Chemistry", title = "Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars", volume = "97", number = "3", pages = "626-633", doi = "10.1002/cche.10278" }
Stikić, R. I., Milinčić, D. D., Kostić, A. Ž., Jovanović, Z., Gašić, U. M., Tešić, Ž. Lj., Djordjević, N. Z., Savić, S. K., Czekus, B. G.,& Pešić, M. B.. (2020). Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. in Cereal Chemistry Wiley-Blackwell., 97(3), 626-633. https://doi.org/10.1002/cche.10278
Stikić RI, Milinčić DD, Kostić AŽ, Jovanović Z, Gašić UM, Tešić ŽL, Djordjević NZ, Savić SK, Czekus BG, Pešić MB. Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. in Cereal Chemistry. 2020;97(3):626-633. doi:10.1002/cche.10278 .
Stikić, Radmila I., Milinčić, Danijel D., Kostić, Aleksandar Ž., Jovanović, Zorica, Gašić, Uroš M., Tešić, Živoslav Lj., Djordjević, Nataša Z., Savić, Slađana K., Czekus, Borisz G., Pešić, Mirjana B., "Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars" in Cereal Chemistry, 97, no. 3 (2020):626-633, https://doi.org/10.1002/cche.10278 . .