Semisynthesis of Taxol (R): an improved procedure far the isolation of 10-deacetylbaccatin III
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From the needles of domestic yew, (Taxus baccata), 10-deacetylbaccatin III (10-DAB) call be isolated in quantities of up to 297 mg per kg of fresh needles. Additional quantities of 10-DAB call be obtained from the extract by NaBH4 mediated reductive hydrolysis of baccatin esters. A four-step procedure converts 10-DAB into taxol in 58% overall yield.
Кључне речи:anti-tumor agents / taxol / natural products / semisynthesis
Извор:Journal of the Serbian Chemical Society, 1999, 64, 9, 497-503
- Serbian Chemical Soc, Belgrade