Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin
Аутори
Jaćević, VesnaDumanović, Jelena
Lazarević, Miodrag
Nepovimova, Eugenie
Resanović, Radmila
Milovanović, Zoran
Wu, Qinghua
Kuča, Kamil
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this paper, the potential antidote efficacy of commercially available formulations of various feed additives such as Minazel-Plus®, Mycosorb®, and Mycofix® was considered by recording their incidence on general health, body weight, and food and water intake, as well as through histopathology and semiquantitative analysis of gastric alterations in Wistar rats treated with the T-2 toxin in a single-dose regimen of 1.67 mg/kg p.o. (1 LD50) for 4 weeks. As an organic adsorbent, Mycosorb® successfully antagonized acute lethal incidence of the T-2 toxin (protective index (PI) = 2.25; p < 0.05 vs. T-2 toxin), and had adverse effects on body weight gain as well as food and water intake during the research (p < 0.001). However, the protective efficacy of the other two food additives was significantly lower (p < 0.05). Treatment with Mycosorb® significantly reduced the severity of gastric damage, which was not the case when the other two adsorbents were used. Our ...results suggest that Mycosorb® is a much better adsorbent for preventing the adverse impact of the T-2 toxin as well as its toxic metabolites compared with Minazel-plus® or Mycofix-plus®, and it almost completely suppresses its acute toxic effects and cytotoxic potential on the gastric epithelial, glandular, and vascular endothelial cells.
Кључне речи:
adsorbents / antidote / rats / T-2 toxinИзвор:
Toxins, 2020, 12, 10, 643-Издавач:
- MDPI
Финансирање / пројекти:
- The University of Hradec Kralove (Faculty of Science VT2019-2021), Czech Republic.
- National Natural Science Foundation of China (grant no. 31972741) supported this work.
- The Medical Faculty of the Military Medical Academy.
- University of Defence in Belgrade, Republic of Serbia (MFVMA/04/20-22.
DOI: 10.3390/toxins12100643
ISSN: 2072-6651
WoS: 000585352000001
Scopus: 2-s2.0-85092287956
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Jaćević, Vesna AU - Dumanović, Jelena AU - Lazarević, Miodrag AU - Nepovimova, Eugenie AU - Resanović, Radmila AU - Milovanović, Zoran AU - Wu, Qinghua AU - Kuča, Kamil PY - 2020 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4258 AB - In this paper, the potential antidote efficacy of commercially available formulations of various feed additives such as Minazel-Plus®, Mycosorb®, and Mycofix® was considered by recording their incidence on general health, body weight, and food and water intake, as well as through histopathology and semiquantitative analysis of gastric alterations in Wistar rats treated with the T-2 toxin in a single-dose regimen of 1.67 mg/kg p.o. (1 LD50) for 4 weeks. As an organic adsorbent, Mycosorb® successfully antagonized acute lethal incidence of the T-2 toxin (protective index (PI) = 2.25; p < 0.05 vs. T-2 toxin), and had adverse effects on body weight gain as well as food and water intake during the research (p < 0.001). However, the protective efficacy of the other two food additives was significantly lower (p < 0.05). Treatment with Mycosorb® significantly reduced the severity of gastric damage, which was not the case when the other two adsorbents were used. Our results suggest that Mycosorb® is a much better adsorbent for preventing the adverse impact of the T-2 toxin as well as its toxic metabolites compared with Minazel-plus® or Mycofix-plus®, and it almost completely suppresses its acute toxic effects and cytotoxic potential on the gastric epithelial, glandular, and vascular endothelial cells. PB - MDPI T2 - Toxins T1 - Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin VL - 12 IS - 10 SP - 643 DO - 10.3390/toxins12100643 ER -
@article{ author = "Jaćević, Vesna and Dumanović, Jelena and Lazarević, Miodrag and Nepovimova, Eugenie and Resanović, Radmila and Milovanović, Zoran and Wu, Qinghua and Kuča, Kamil", year = "2020", abstract = "In this paper, the potential antidote efficacy of commercially available formulations of various feed additives such as Minazel-Plus®, Mycosorb®, and Mycofix® was considered by recording their incidence on general health, body weight, and food and water intake, as well as through histopathology and semiquantitative analysis of gastric alterations in Wistar rats treated with the T-2 toxin in a single-dose regimen of 1.67 mg/kg p.o. (1 LD50) for 4 weeks. As an organic adsorbent, Mycosorb® successfully antagonized acute lethal incidence of the T-2 toxin (protective index (PI) = 2.25; p < 0.05 vs. T-2 toxin), and had adverse effects on body weight gain as well as food and water intake during the research (p < 0.001). However, the protective efficacy of the other two food additives was significantly lower (p < 0.05). Treatment with Mycosorb® significantly reduced the severity of gastric damage, which was not the case when the other two adsorbents were used. Our results suggest that Mycosorb® is a much better adsorbent for preventing the adverse impact of the T-2 toxin as well as its toxic metabolites compared with Minazel-plus® or Mycofix-plus®, and it almost completely suppresses its acute toxic effects and cytotoxic potential on the gastric epithelial, glandular, and vascular endothelial cells.", publisher = "MDPI", journal = "Toxins", title = "Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin", volume = "12", number = "10", pages = "643", doi = "10.3390/toxins12100643" }
Jaćević, V., Dumanović, J., Lazarević, M., Nepovimova, E., Resanović, R., Milovanović, Z., Wu, Q.,& Kuča, K.. (2020). Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin. in Toxins MDPI., 12(10), 643. https://doi.org/10.3390/toxins12100643
Jaćević V, Dumanović J, Lazarević M, Nepovimova E, Resanović R, Milovanović Z, Wu Q, Kuča K. Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin. in Toxins. 2020;12(10):643. doi:10.3390/toxins12100643 .
Jaćević, Vesna, Dumanović, Jelena, Lazarević, Miodrag, Nepovimova, Eugenie, Resanović, Radmila, Milovanović, Zoran, Wu, Qinghua, Kuča, Kamil, "Antidotal Potency of the Novel, Structurally Different Adsorbents in Rats Acutely Intoxicated with the T-2 Toxin" in Toxins, 12, no. 10 (2020):643, https://doi.org/10.3390/toxins12100643 . .