New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria
Аутори
Opsenica, IgorSelaković, Milica
Tot, Mikloš
Verbić, Tatjana
Srbljanović, Jelena
Štajner, Tijana
Đurković-Đaković, Olgica
Šolaja, Bogdan A.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P. falciparum strains, 3D7 (CQ susceptible clone) and Dd2 (CQ resistant clone). Three aminoquinolines were further examined for antimalarial efficacy in a mouse model using a modified Thompson test. In this model, mice were infected with P. berghei-infected red blood cells, and drugs were administered orally. Antimalarial 3 was found toxic at a dose of 320 (mg/kg)/day in 3/6 mice, however, 2/6 mice of the same group survived through day 31, and one of them was cured. © 2021 Serbian Chemical Society. All rights reserved.
Кључне речи:
Antimalarials / Bromobenzyl derivatives / Quinoline / β-hematin inhibitory activityИзвор:
Journal of the Serbian Chemical Society, 2021, 86, 2, 115-123Издавач:
- Belgrade : Serbian Chemical Society
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-MESTD-inst-2020-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200288 (Иновациони центар Хемијског факултета у Београду доо) (RS-MESTD-inst-2020-200288)
- Serbian Academy of Sciences and Arts, project F-80
Напомена:
- Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/4392
Повезане информације:
- Верзија документа
https://doi.org/10.2298/JSC201225005O - Референца
https://cherry.chem.bg.ac.rs/handle/123456789/4392
DOI: 10.2298/JSC201225005O
ISSN: 0352-5139
WoS: 000639574500001
Scopus: 2-s2.0-85102648212
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Opsenica, Igor AU - Selaković, Milica AU - Tot, Mikloš AU - Verbić, Tatjana AU - Srbljanović, Jelena AU - Štajner, Tijana AU - Đurković-Đaković, Olgica AU - Šolaja, Bogdan A. PY - 2021 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4389 AB - Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P. falciparum strains, 3D7 (CQ susceptible clone) and Dd2 (CQ resistant clone). Three aminoquinolines were further examined for antimalarial efficacy in a mouse model using a modified Thompson test. In this model, mice were infected with P. berghei-infected red blood cells, and drugs were administered orally. Antimalarial 3 was found toxic at a dose of 320 (mg/kg)/day in 3/6 mice, however, 2/6 mice of the same group survived through day 31, and one of them was cured. © 2021 Serbian Chemical Society. All rights reserved. PB - Belgrade : Serbian Chemical Society T2 - Journal of the Serbian Chemical Society T1 - New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria VL - 86 IS - 2 SP - 115 EP - 123 DO - 10.2298/JSC201225005O ER -
@article{ author = "Opsenica, Igor and Selaković, Milica and Tot, Mikloš and Verbić, Tatjana and Srbljanović, Jelena and Štajner, Tijana and Đurković-Đaković, Olgica and Šolaja, Bogdan A.", year = "2021", abstract = "Synthesis of novel aminoquinoline derivatives has been accomplished and their activity against malaria strains has been examined. The compounds showed moderate in vitro antimalarial activity against two P. falciparum strains, 3D7 (CQ susceptible clone) and Dd2 (CQ resistant clone). Three aminoquinolines were further examined for antimalarial efficacy in a mouse model using a modified Thompson test. In this model, mice were infected with P. berghei-infected red blood cells, and drugs were administered orally. Antimalarial 3 was found toxic at a dose of 320 (mg/kg)/day in 3/6 mice, however, 2/6 mice of the same group survived through day 31, and one of them was cured. © 2021 Serbian Chemical Society. All rights reserved.", publisher = "Belgrade : Serbian Chemical Society", journal = "Journal of the Serbian Chemical Society", title = "New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria", volume = "86", number = "2", pages = "115-123", doi = "10.2298/JSC201225005O" }
Opsenica, I., Selaković, M., Tot, M., Verbić, T., Srbljanović, J., Štajner, T., Đurković-Đaković, O.,& Šolaja, B. A.. (2021). New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria. in Journal of the Serbian Chemical Society Belgrade : Serbian Chemical Society., 86(2), 115-123. https://doi.org/10.2298/JSC201225005O
Opsenica I, Selaković M, Tot M, Verbić T, Srbljanović J, Štajner T, Đurković-Đaković O, Šolaja BA. New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria. in Journal of the Serbian Chemical Society. 2021;86(2):115-123. doi:10.2298/JSC201225005O .
Opsenica, Igor, Selaković, Milica, Tot, Mikloš, Verbić, Tatjana, Srbljanović, Jelena, Štajner, Tijana, Đurković-Đaković, Olgica, Šolaja, Bogdan A., "New 4-aminoquinolines as moderate inhibitors of P. falciparum malaria" in Journal of the Serbian Chemical Society, 86, no. 2 (2021):115-123, https://doi.org/10.2298/JSC201225005O . .