Phenolic compounds and biopotential of grape pomace extracts from Prokupac red grape variety
Само за регистроване кориснике
2021
Аутори
Milinčić, Danijel D.Stanisavljević, Nemanja S.
Kostić, Aleksandar Ž.
Soković Bajić, Svetlana
Kojić, Milan O.
Gašić, Uroš M.
Barać, Miroljub B.
Stanojević, Slađana P.
Tešić, Živoslav Lj.
Pešić, Mirjana B.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Phenolic compounds and biopotential (antioxidant, cellular antioxidant and cytotoxic activity) of grape pomace (GP) skin, seed, stem and whole GP originating from indigenous red grape variety Prokupac were evaluated. The UHPLC-Orbitrap MS4 analysis showed the presence of 75 phenolic compounds (57 non-anthocyanins and 18 anthocyanins), among which considerable content of ethyl gallate was observed and malvidin-3-O-hexoside-(8,8)-methylmethyne-(epi)catechin was identified. The stem had significant content of stilbenoids. The GP seed and the whole GP showed the highest antioxidant activity estimated by ABTS•+ DPPH• and H2O2 scavenging assays that were strongly correlated with the presence of flavan-3-ols, phenolic acids and ethyl gallate. The GP skin exerted cellular antioxidant activity on adenocarcinoma cells (EC50 = 56.4 mg TPCs/mL) which was strongly correlated with the presence of flavonols and anthocyanins. These by-products of Prokupac red grape variety are a notable source of phen...olic compounds with good antioxidant activity that can be extensively used in food and pharmaceutical industry.
Кључне речи:
Antioxidant activity / Cellular antioxidant activity / Cytotoxic activity / Phenolic compounds / Wine by-productsИзвор:
LWT, 2021, 138, 110739-Издавач:
- Elsevier
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200116 (Универзитет у Београду, Пољопривредни факултет) (RS-200116)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-200007)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200042 (Универзитет у Београду, Институт за молекуларну генетику и генетичко инжењерство) (RS-200042)
Напомена:
- Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/4449
Повезане информације:
DOI: 10.1016/j.lwt.2020.110739
ISSN: 0023-6438
WoS: 000608242300085
Scopus: 2-s2.0-85098179864
URI
https://www.sciencedirect.com/science/article/pii/S0023643820317278https://cherry.chem.bg.ac.rs/handle/123456789/4448
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Milinčić, Danijel D. AU - Stanisavljević, Nemanja S. AU - Kostić, Aleksandar Ž. AU - Soković Bajić, Svetlana AU - Kojić, Milan O. AU - Gašić, Uroš M. AU - Barać, Miroljub B. AU - Stanojević, Slađana P. AU - Tešić, Živoslav Lj. AU - Pešić, Mirjana B. PY - 2021 UR - https://www.sciencedirect.com/science/article/pii/S0023643820317278 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4448 AB - Phenolic compounds and biopotential (antioxidant, cellular antioxidant and cytotoxic activity) of grape pomace (GP) skin, seed, stem and whole GP originating from indigenous red grape variety Prokupac were evaluated. The UHPLC-Orbitrap MS4 analysis showed the presence of 75 phenolic compounds (57 non-anthocyanins and 18 anthocyanins), among which considerable content of ethyl gallate was observed and malvidin-3-O-hexoside-(8,8)-methylmethyne-(epi)catechin was identified. The stem had significant content of stilbenoids. The GP seed and the whole GP showed the highest antioxidant activity estimated by ABTS•+ DPPH• and H2O2 scavenging assays that were strongly correlated with the presence of flavan-3-ols, phenolic acids and ethyl gallate. The GP skin exerted cellular antioxidant activity on adenocarcinoma cells (EC50 = 56.4 mg TPCs/mL) which was strongly correlated with the presence of flavonols and anthocyanins. These by-products of Prokupac red grape variety are a notable source of phenolic compounds with good antioxidant activity that can be extensively used in food and pharmaceutical industry. PB - Elsevier T2 - LWT T1 - Phenolic compounds and biopotential of grape pomace extracts from Prokupac red grape variety VL - 138 SP - 110739 DO - 10.1016/j.lwt.2020.110739 ER -
@article{ author = "Milinčić, Danijel D. and Stanisavljević, Nemanja S. and Kostić, Aleksandar Ž. and Soković Bajić, Svetlana and Kojić, Milan O. and Gašić, Uroš M. and Barać, Miroljub B. and Stanojević, Slađana P. and Tešić, Živoslav Lj. and Pešić, Mirjana B.", year = "2021", abstract = "Phenolic compounds and biopotential (antioxidant, cellular antioxidant and cytotoxic activity) of grape pomace (GP) skin, seed, stem and whole GP originating from indigenous red grape variety Prokupac were evaluated. The UHPLC-Orbitrap MS4 analysis showed the presence of 75 phenolic compounds (57 non-anthocyanins and 18 anthocyanins), among which considerable content of ethyl gallate was observed and malvidin-3-O-hexoside-(8,8)-methylmethyne-(epi)catechin was identified. The stem had significant content of stilbenoids. The GP seed and the whole GP showed the highest antioxidant activity estimated by ABTS•+ DPPH• and H2O2 scavenging assays that were strongly correlated with the presence of flavan-3-ols, phenolic acids and ethyl gallate. The GP skin exerted cellular antioxidant activity on adenocarcinoma cells (EC50 = 56.4 mg TPCs/mL) which was strongly correlated with the presence of flavonols and anthocyanins. These by-products of Prokupac red grape variety are a notable source of phenolic compounds with good antioxidant activity that can be extensively used in food and pharmaceutical industry.", publisher = "Elsevier", journal = "LWT", title = "Phenolic compounds and biopotential of grape pomace extracts from Prokupac red grape variety", volume = "138", pages = "110739", doi = "10.1016/j.lwt.2020.110739" }
Milinčić, D. D., Stanisavljević, N. S., Kostić, A. Ž., Soković Bajić, S., Kojić, M. O., Gašić, U. M., Barać, M. B., Stanojević, S. P., Tešić, Ž. Lj.,& Pešić, M. B.. (2021). Phenolic compounds and biopotential of grape pomace extracts from Prokupac red grape variety. in LWT Elsevier., 138, 110739. https://doi.org/10.1016/j.lwt.2020.110739
Milinčić DD, Stanisavljević NS, Kostić AŽ, Soković Bajić S, Kojić MO, Gašić UM, Barać MB, Stanojević SP, Tešić ŽL, Pešić MB. Phenolic compounds and biopotential of grape pomace extracts from Prokupac red grape variety. in LWT. 2021;138:110739. doi:10.1016/j.lwt.2020.110739 .
Milinčić, Danijel D., Stanisavljević, Nemanja S., Kostić, Aleksandar Ž., Soković Bajić, Svetlana, Kojić, Milan O., Gašić, Uroš M., Barać, Miroljub B., Stanojević, Slađana P., Tešić, Živoslav Lj., Pešić, Mirjana B., "Phenolic compounds and biopotential of grape pomace extracts from Prokupac red grape variety" in LWT, 138 (2021):110739, https://doi.org/10.1016/j.lwt.2020.110739 . .