Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents
Само за регистроване кориснике
2021
Аутори
Stevanović, NevenaMazzeo, Paolo Pio
Bacchi, Alessia
Matić, Ivana Z.
Đorđić Crnogorac, Marija
Stanojković, Tatjana
Vujčić, Miroslava
Novaković, Irena T.
Radanović, Dušanka D.
Šumar-Ristović, Maja
Sladić, Dušan
Čobeljić, Božidar
Anđelković, Katarina K.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this work synthesis, characterization and crystal structures of 1, Zn(II) complex ([ZnL1(NCS)2]), with (E)-1-(2-oxo-2-(2-(quinolin-2-ylmethylene)hydrazinyl)ethyl)pyridin-1-ium chloride (HL1Cl) and 2, Bi(III) complex ([BiHL2Cl4] × 1/2CH3OH), with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL2Cl), have been reported. Zn(II) complex possesses a distorted trigonal bipyramidal geometry while surroundings around Bi(III) ion are extended pentagonal bipyramidal. Antimicrobial activity, brine shrimp assay and DPPH radical scavenging activity of both complexes, including previously synthesized complexes with HL2Cl ligand (Zn(II) and Ni(II)) and complexes with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL3Cl) (Zn(II), Cu(II), Cd(II), Co(II), Fe(III), Ni(II)), were evaluated. For the most active complexes, cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 a...nd A549) and normal cell line HaCaT, as well as generation of reactive oxygen species (ROS), was tested.
Кључне речи:
Hydrazone complexes / X-ray / Antimicrobial activity / Cytotoxic activity / ROS / DNA-binding experimentsИзвор:
JBIC Journal of Biological Inorganic Chemistry, 2021, 26, 863-880Издавач:
- Springer
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200026 (Универзитет у Београду, Институт за хемију, технологију и металургију - ИХТМ) (RS-200026)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-200168)
Напомена:
- Supplementary material: https://cherry.chem.bg.ac.rs/handle/123456789/4675
Повезане информације:
DOI: 10.1007/s00775-021-01893-5
ISSN: 0949-8257
WoS: 000695511900001
Scopus: 2-s2.0-85114304815
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Stevanović, Nevena AU - Mazzeo, Paolo Pio AU - Bacchi, Alessia AU - Matić, Ivana Z. AU - Đorđić Crnogorac, Marija AU - Stanojković, Tatjana AU - Vujčić, Miroslava AU - Novaković, Irena T. AU - Radanović, Dušanka D. AU - Šumar-Ristović, Maja AU - Sladić, Dušan AU - Čobeljić, Božidar AU - Anđelković, Katarina K. PY - 2021 UR - https://cherry.chem.bg.ac.rs/handle/123456789/4673 AB - In this work synthesis, characterization and crystal structures of 1, Zn(II) complex ([ZnL1(NCS)2]), with (E)-1-(2-oxo-2-(2-(quinolin-2-ylmethylene)hydrazinyl)ethyl)pyridin-1-ium chloride (HL1Cl) and 2, Bi(III) complex ([BiHL2Cl4] × 1/2CH3OH), with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL2Cl), have been reported. Zn(II) complex possesses a distorted trigonal bipyramidal geometry while surroundings around Bi(III) ion are extended pentagonal bipyramidal. Antimicrobial activity, brine shrimp assay and DPPH radical scavenging activity of both complexes, including previously synthesized complexes with HL2Cl ligand (Zn(II) and Ni(II)) and complexes with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL3Cl) (Zn(II), Cu(II), Cd(II), Co(II), Fe(III), Ni(II)), were evaluated. For the most active complexes, cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and normal cell line HaCaT, as well as generation of reactive oxygen species (ROS), was tested. PB - Springer T2 - JBIC Journal of Biological Inorganic Chemistry T1 - Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents VL - 26 SP - 863 EP - 880 DO - 10.1007/s00775-021-01893-5 ER -
@article{ author = "Stevanović, Nevena and Mazzeo, Paolo Pio and Bacchi, Alessia and Matić, Ivana Z. and Đorđić Crnogorac, Marija and Stanojković, Tatjana and Vujčić, Miroslava and Novaković, Irena T. and Radanović, Dušanka D. and Šumar-Ristović, Maja and Sladić, Dušan and Čobeljić, Božidar and Anđelković, Katarina K.", year = "2021", abstract = "In this work synthesis, characterization and crystal structures of 1, Zn(II) complex ([ZnL1(NCS)2]), with (E)-1-(2-oxo-2-(2-(quinolin-2-ylmethylene)hydrazinyl)ethyl)pyridin-1-ium chloride (HL1Cl) and 2, Bi(III) complex ([BiHL2Cl4] × 1/2CH3OH), with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL2Cl), have been reported. Zn(II) complex possesses a distorted trigonal bipyramidal geometry while surroundings around Bi(III) ion are extended pentagonal bipyramidal. Antimicrobial activity, brine shrimp assay and DPPH radical scavenging activity of both complexes, including previously synthesized complexes with HL2Cl ligand (Zn(II) and Ni(II)) and complexes with (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride (HL3Cl) (Zn(II), Cu(II), Cd(II), Co(II), Fe(III), Ni(II)), were evaluated. For the most active complexes, cytotoxic activity against five malignant cancer cell lines (HeLa, A375, MCF7, PC-3 and A549) and normal cell line HaCaT, as well as generation of reactive oxygen species (ROS), was tested.", publisher = "Springer", journal = "JBIC Journal of Biological Inorganic Chemistry", title = "Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents", volume = "26", pages = "863-880", doi = "10.1007/s00775-021-01893-5" }
Stevanović, N., Mazzeo, P. P., Bacchi, A., Matić, I. Z., Đorđić Crnogorac, M., Stanojković, T., Vujčić, M., Novaković, I. T., Radanović, D. D., Šumar-Ristović, M., Sladić, D., Čobeljić, B.,& Anđelković, K. K.. (2021). Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents. in JBIC Journal of Biological Inorganic Chemistry Springer., 26, 863-880. https://doi.org/10.1007/s00775-021-01893-5
Stevanović N, Mazzeo PP, Bacchi A, Matić IZ, Đorđić Crnogorac M, Stanojković T, Vujčić M, Novaković IT, Radanović DD, Šumar-Ristović M, Sladić D, Čobeljić B, Anđelković KK. Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents. in JBIC Journal of Biological Inorganic Chemistry. 2021;26:863-880. doi:10.1007/s00775-021-01893-5 .
Stevanović, Nevena, Mazzeo, Paolo Pio, Bacchi, Alessia, Matić, Ivana Z., Đorđić Crnogorac, Marija, Stanojković, Tatjana, Vujčić, Miroslava, Novaković, Irena T., Radanović, Dušanka D., Šumar-Ristović, Maja, Sladić, Dušan, Čobeljić, Božidar, Anđelković, Katarina K., "Synthesis, characterization, antimicrobial and cytotoxic activity and DNA-binding properties of d-metal complexes with hydrazones of Girard’s T and P reagents" in JBIC Journal of Biological Inorganic Chemistry, 26 (2021):863-880, https://doi.org/10.1007/s00775-021-01893-5 . .