The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas
Само за регистроване кориснике
2021
Аутори
Jagodić, JovanaRovčanin, Branislav
Paunović, Ivan
Jovanović, Milan
Gavrović-Jankulović, Marija
Manojlović, Dragan D.
Stojsavljević, Aleksandar
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background
The baseline status of trace metals in adrenal tissue is unresolved, while the elemental profile for any adrenal pathology has not been examined so far. This study aimed to determine the baseline status of important toxic (Ni, As, Cd, Pb, Th, U) and essential trace elements (Mn, Co, Cu, Zn, Se) in healthy adrenal tissues (HATs) as well as to examine whether there are alterations in the elemental composition of adenomatous adrenal tissues (AATs). Furthermore, this study aimed to find potential trace metals that could play a role in the pathogenesis of adrenal adenoma (AA).
Methods
The study included 45 patients diagnosed with AA. Impacts of relevant parameters such as gender, age, smoking habits and nodular sizes were considered. All samples were subjected to microwave digestion and the trace elements were determined by inductively coupled plasma mass spectrometry (ICP-MS).
Results
This is the first study that provided an insight into the elemental status of HATs. It... was also shown that AATs had altered trace metal contents. Compared to HATs, the most significant findings were related to the high content of essential (Cu, Mn, Se, Zn) and Pb as a non-essential metal. Although gender, age and smoking habits had a modest effect on metal profiles, the most significant alterations were related to the nodular diameter above 4 cm, indicating that the growth of benign tumor could influence changes in elemental composition.
Conclusion
For the first time the baseline contents of essential and toxic trace metals in HATs were determined. The results of this study may highlight the role of toxic and essential trace metals in AAs and could provide new insights into the molecular basis of pathophysiological changes caused by the hazardous effects of trace metals on adrenal structure and function.
Кључне речи:
Trace metals (toxic/essential) / Adrenal adenoma (AA) / Healthy adrenal tissue (HAT) / Adenomatous adrenal tissue (AAT) / PathogenesisИзвор:
Journal of Trace Elements in Medicine and Biology, 2021, 63, 126658-Издавач:
- Elsevier
Финансирање / пројекти:
DOI: 10.1016/j.jtemb.2020.126658
ISSN: 0946-672X
WoS: 000597382100004
Scopus: 2-s2.0-85092015870
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Jagodić, Jovana AU - Rovčanin, Branislav AU - Paunović, Ivan AU - Jovanović, Milan AU - Gavrović-Jankulović, Marija AU - Manojlović, Dragan D. AU - Stojsavljević, Aleksandar PY - 2021 UR - http://cherry.chem.bg.ac.rs/handle/123456789/4787 AB - Background The baseline status of trace metals in adrenal tissue is unresolved, while the elemental profile for any adrenal pathology has not been examined so far. This study aimed to determine the baseline status of important toxic (Ni, As, Cd, Pb, Th, U) and essential trace elements (Mn, Co, Cu, Zn, Se) in healthy adrenal tissues (HATs) as well as to examine whether there are alterations in the elemental composition of adenomatous adrenal tissues (AATs). Furthermore, this study aimed to find potential trace metals that could play a role in the pathogenesis of adrenal adenoma (AA). Methods The study included 45 patients diagnosed with AA. Impacts of relevant parameters such as gender, age, smoking habits and nodular sizes were considered. All samples were subjected to microwave digestion and the trace elements were determined by inductively coupled plasma mass spectrometry (ICP-MS). Results This is the first study that provided an insight into the elemental status of HATs. It was also shown that AATs had altered trace metal contents. Compared to HATs, the most significant findings were related to the high content of essential (Cu, Mn, Se, Zn) and Pb as a non-essential metal. Although gender, age and smoking habits had a modest effect on metal profiles, the most significant alterations were related to the nodular diameter above 4 cm, indicating that the growth of benign tumor could influence changes in elemental composition. Conclusion For the first time the baseline contents of essential and toxic trace metals in HATs were determined. The results of this study may highlight the role of toxic and essential trace metals in AAs and could provide new insights into the molecular basis of pathophysiological changes caused by the hazardous effects of trace metals on adrenal structure and function. PB - Elsevier T2 - Journal of Trace Elements in Medicine and Biology T1 - The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas VL - 63 SP - 126658 DO - 10.1016/j.jtemb.2020.126658 ER -
@article{ author = "Jagodić, Jovana and Rovčanin, Branislav and Paunović, Ivan and Jovanović, Milan and Gavrović-Jankulović, Marija and Manojlović, Dragan D. and Stojsavljević, Aleksandar", year = "2021", abstract = "Background The baseline status of trace metals in adrenal tissue is unresolved, while the elemental profile for any adrenal pathology has not been examined so far. This study aimed to determine the baseline status of important toxic (Ni, As, Cd, Pb, Th, U) and essential trace elements (Mn, Co, Cu, Zn, Se) in healthy adrenal tissues (HATs) as well as to examine whether there are alterations in the elemental composition of adenomatous adrenal tissues (AATs). Furthermore, this study aimed to find potential trace metals that could play a role in the pathogenesis of adrenal adenoma (AA). Methods The study included 45 patients diagnosed with AA. Impacts of relevant parameters such as gender, age, smoking habits and nodular sizes were considered. All samples were subjected to microwave digestion and the trace elements were determined by inductively coupled plasma mass spectrometry (ICP-MS). Results This is the first study that provided an insight into the elemental status of HATs. It was also shown that AATs had altered trace metal contents. Compared to HATs, the most significant findings were related to the high content of essential (Cu, Mn, Se, Zn) and Pb as a non-essential metal. Although gender, age and smoking habits had a modest effect on metal profiles, the most significant alterations were related to the nodular diameter above 4 cm, indicating that the growth of benign tumor could influence changes in elemental composition. Conclusion For the first time the baseline contents of essential and toxic trace metals in HATs were determined. The results of this study may highlight the role of toxic and essential trace metals in AAs and could provide new insights into the molecular basis of pathophysiological changes caused by the hazardous effects of trace metals on adrenal structure and function.", publisher = "Elsevier", journal = "Journal of Trace Elements in Medicine and Biology", title = "The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas", volume = "63", pages = "126658", doi = "10.1016/j.jtemb.2020.126658" }
Jagodić, J., Rovčanin, B., Paunović, I., Jovanović, M., Gavrović-Jankulović, M., Manojlović, D. D.,& Stojsavljević, A.. (2021). The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas. in Journal of Trace Elements in Medicine and Biology Elsevier., 63, 126658. https://doi.org/10.1016/j.jtemb.2020.126658
Jagodić J, Rovčanin B, Paunović I, Jovanović M, Gavrović-Jankulović M, Manojlović DD, Stojsavljević A. The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas. in Journal of Trace Elements in Medicine and Biology. 2021;63:126658. doi:10.1016/j.jtemb.2020.126658 .
Jagodić, Jovana, Rovčanin, Branislav, Paunović, Ivan, Jovanović, Milan, Gavrović-Jankulović, Marija, Manojlović, Dragan D., Stojsavljević, Aleksandar, "The first insight into the trace element status of human adrenal gland accompanied by elemental alterations in adrenal adenomas" in Journal of Trace Elements in Medicine and Biology, 63 (2021):126658, https://doi.org/10.1016/j.jtemb.2020.126658 . .