The new ruthenium(II)-bipyridyl complex as potential PDT agent: Synthesis and characterization
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The new bipyridyl complex of ruthenium(II) with O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2-
(3-cyclohexyl)propanoate was synthesized. The reaction of cis-[RuCl2(bpy)2] and its ligand was performed in water/ethanol solution, in the presence of lithium hydroxide, under reflux. After the addition of
ammonium hexafluorophosphate, the complex was precipitated. The complex, cis-[Ru(bpy)2L](PF6)2, was
characterized by 1H and 13C NMR, UV-Vis, IR spectroscopy, ESI-MS spectrometry and elemental analysis. Results indicate an octahedral geometry of the complex, with N,N'-coordinated O,O'-diethyl-(S,S)-
ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate. Complexes of this type are particularly important
in terms of potential cytotoxicity and application in photodynamic therapy. Using this therapy, many side
effects can be reduced, which may allow the administration of higher drug dosages.
Кључне речи:
ruthenium(II) complexes / edda-type ligand / photodynamic therapyИзвор:
Macedonian Journal of Chemistry and Chemical Engineering, 2014, 33, 59-64Издавач:
- Society of Chemists and Technologists of Macedonia
Финансирање / пројекти:
- Рационални дизајн и синтеза биолошки активних и координационих једињења и функционалних материјала, релевантних у (био)нанотехнологији (RS-MESTD-Basic Research (BR or ON)-172035)
DOI: 10.20450/mjcce.2014.424
ISSN: 1857-5552
WoS: 000336241300006
Scopus: 2-s2.0-84902580817
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Savić, Aleksandar AU - Baroud, Afya A. AU - Grgurić-Šipka, Sanja PY - 2014 UR - http://cherry.chem.bg.ac.rs/handle/123456789/5073 AB - The new bipyridyl complex of ruthenium(II) with O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2- (3-cyclohexyl)propanoate was synthesized. The reaction of cis-[RuCl2(bpy)2] and its ligand was performed in water/ethanol solution, in the presence of lithium hydroxide, under reflux. After the addition of ammonium hexafluorophosphate, the complex was precipitated. The complex, cis-[Ru(bpy)2L](PF6)2, was characterized by 1H and 13C NMR, UV-Vis, IR spectroscopy, ESI-MS spectrometry and elemental analysis. Results indicate an octahedral geometry of the complex, with N,N'-coordinated O,O'-diethyl-(S,S)- ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate. Complexes of this type are particularly important in terms of potential cytotoxicity and application in photodynamic therapy. Using this therapy, many side effects can be reduced, which may allow the administration of higher drug dosages. PB - Society of Chemists and Technologists of Macedonia T2 - Macedonian Journal of Chemistry and Chemical Engineering T1 - The new ruthenium(II)-bipyridyl complex as potential PDT agent: Synthesis and characterization VL - 33 SP - 59 EP - 64 DO - 10.20450/mjcce.2014.424 ER -
@article{ author = "Savić, Aleksandar and Baroud, Afya A. and Grgurić-Šipka, Sanja", year = "2014", abstract = "The new bipyridyl complex of ruthenium(II) with O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2- (3-cyclohexyl)propanoate was synthesized. The reaction of cis-[RuCl2(bpy)2] and its ligand was performed in water/ethanol solution, in the presence of lithium hydroxide, under reflux. After the addition of ammonium hexafluorophosphate, the complex was precipitated. The complex, cis-[Ru(bpy)2L](PF6)2, was characterized by 1H and 13C NMR, UV-Vis, IR spectroscopy, ESI-MS spectrometry and elemental analysis. Results indicate an octahedral geometry of the complex, with N,N'-coordinated O,O'-diethyl-(S,S)- ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate. Complexes of this type are particularly important in terms of potential cytotoxicity and application in photodynamic therapy. Using this therapy, many side effects can be reduced, which may allow the administration of higher drug dosages.", publisher = "Society of Chemists and Technologists of Macedonia", journal = "Macedonian Journal of Chemistry and Chemical Engineering", title = "The new ruthenium(II)-bipyridyl complex as potential PDT agent: Synthesis and characterization", volume = "33", pages = "59-64", doi = "10.20450/mjcce.2014.424" }
Savić, A., Baroud, A. A.,& Grgurić-Šipka, S.. (2014). The new ruthenium(II)-bipyridyl complex as potential PDT agent: Synthesis and characterization. in Macedonian Journal of Chemistry and Chemical Engineering Society of Chemists and Technologists of Macedonia., 33, 59-64. https://doi.org/10.20450/mjcce.2014.424
Savić A, Baroud AA, Grgurić-Šipka S. The new ruthenium(II)-bipyridyl complex as potential PDT agent: Synthesis and characterization. in Macedonian Journal of Chemistry and Chemical Engineering. 2014;33:59-64. doi:10.20450/mjcce.2014.424 .
Savić, Aleksandar, Baroud, Afya A., Grgurić-Šipka, Sanja, "The new ruthenium(II)-bipyridyl complex as potential PDT agent: Synthesis and characterization" in Macedonian Journal of Chemistry and Chemical Engineering, 33 (2014):59-64, https://doi.org/10.20450/mjcce.2014.424 . .