Levels of non-essential trace metals and their impact on placental health: a review
Само за регистроване кориснике
2022
Аутори
Stojsavljević, AleksandarPerović, Milan
Nešić, Andrijana N.
Miković, Željko
Manojlović, Dragan D.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
According to recent research, even low levels of environmental chemicals, particularly heavy metals, can considerably disrupt placental homeostasis. This review aims to explore the profile of non-essential trace metals in placental tissues across the globe and to specify trace metal(s) that can be candidates for impaired placental health. Accordingly, we conducted an extensive survey on relevant databases of peer-reviewed papers published in the last two decades. Among a considerable number of non-essential trace metals, arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) were identified as the most detrimental to placental health. Comparative analysis showed remarkable differences in placental levels of these trace metals worldwide. Based on current data reported across the globe, a median (min–max) range from 0.55 to 15 ng/g for placental As levels could be deemed safe. The placental Cd and Pb levels were markedly higher in smokers than in non-smokers. Occupationally exposed preg...nant women had several orders of magnitude higher Cd, Pb, and Hg levels in placental tissues than non-occupationally exposed women. Also, we concluded that even low-level exposure to As, Cd, Pb, and Hg could be deleterious to proper fetal development. This review implies the need to reduce exposure to non-essential trace metals to preserve placental health and prevent numerous poor pregnancy outcomes. Overall, the information presented is expected to help plan future fundamental and applied investigations on the placental toxicity of As, Cd, Pb, and Hg. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Кључне речи:
Non-essential trace metal / Placenta / Environment / Pregnancy / Smoker / Non-essential trace metalИзвор:
Environmental Science and Pollution Research, 2022, 29, 43662-43674Издавач:
- SpringerLink
Финансирање / пројекти:
DOI: 10.1007/s11356-022-20205-1
ISSN: 0944-1344
WoS: 00078255010000
Scopus: 2-s2.0-85128029385
URI
https://link.springer.com/article/10.1007/s11356-022-20205-1http://cherry.chem.bg.ac.rs/handle/123456789/5116
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Stojsavljević, Aleksandar AU - Perović, Milan AU - Nešić, Andrijana N. AU - Miković, Željko AU - Manojlović, Dragan D. PY - 2022 UR - https://link.springer.com/article/10.1007/s11356-022-20205-1 UR - http://cherry.chem.bg.ac.rs/handle/123456789/5116 AB - According to recent research, even low levels of environmental chemicals, particularly heavy metals, can considerably disrupt placental homeostasis. This review aims to explore the profile of non-essential trace metals in placental tissues across the globe and to specify trace metal(s) that can be candidates for impaired placental health. Accordingly, we conducted an extensive survey on relevant databases of peer-reviewed papers published in the last two decades. Among a considerable number of non-essential trace metals, arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) were identified as the most detrimental to placental health. Comparative analysis showed remarkable differences in placental levels of these trace metals worldwide. Based on current data reported across the globe, a median (min–max) range from 0.55 to 15 ng/g for placental As levels could be deemed safe. The placental Cd and Pb levels were markedly higher in smokers than in non-smokers. Occupationally exposed pregnant women had several orders of magnitude higher Cd, Pb, and Hg levels in placental tissues than non-occupationally exposed women. Also, we concluded that even low-level exposure to As, Cd, Pb, and Hg could be deleterious to proper fetal development. This review implies the need to reduce exposure to non-essential trace metals to preserve placental health and prevent numerous poor pregnancy outcomes. Overall, the information presented is expected to help plan future fundamental and applied investigations on the placental toxicity of As, Cd, Pb, and Hg. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. PB - SpringerLink T2 - Environmental Science and Pollution Research T1 - Levels of non-essential trace metals and their impact on placental health: a review VL - 29 SP - 43662 EP - 43674 DO - 10.1007/s11356-022-20205-1 ER -
@article{ author = "Stojsavljević, Aleksandar and Perović, Milan and Nešić, Andrijana N. and Miković, Željko and Manojlović, Dragan D.", year = "2022", abstract = "According to recent research, even low levels of environmental chemicals, particularly heavy metals, can considerably disrupt placental homeostasis. This review aims to explore the profile of non-essential trace metals in placental tissues across the globe and to specify trace metal(s) that can be candidates for impaired placental health. Accordingly, we conducted an extensive survey on relevant databases of peer-reviewed papers published in the last two decades. Among a considerable number of non-essential trace metals, arsenic (As), lead (Pb), cadmium (Cd), and mercury (Hg) were identified as the most detrimental to placental health. Comparative analysis showed remarkable differences in placental levels of these trace metals worldwide. Based on current data reported across the globe, a median (min–max) range from 0.55 to 15 ng/g for placental As levels could be deemed safe. The placental Cd and Pb levels were markedly higher in smokers than in non-smokers. Occupationally exposed pregnant women had several orders of magnitude higher Cd, Pb, and Hg levels in placental tissues than non-occupationally exposed women. Also, we concluded that even low-level exposure to As, Cd, Pb, and Hg could be deleterious to proper fetal development. This review implies the need to reduce exposure to non-essential trace metals to preserve placental health and prevent numerous poor pregnancy outcomes. Overall, the information presented is expected to help plan future fundamental and applied investigations on the placental toxicity of As, Cd, Pb, and Hg. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.", publisher = "SpringerLink", journal = "Environmental Science and Pollution Research", title = "Levels of non-essential trace metals and their impact on placental health: a review", volume = "29", pages = "43662-43674", doi = "10.1007/s11356-022-20205-1" }
Stojsavljević, A., Perović, M., Nešić, A. N., Miković, Ž.,& Manojlović, D. D.. (2022). Levels of non-essential trace metals and their impact on placental health: a review. in Environmental Science and Pollution Research SpringerLink., 29, 43662-43674. https://doi.org/10.1007/s11356-022-20205-1
Stojsavljević A, Perović M, Nešić AN, Miković Ž, Manojlović DD. Levels of non-essential trace metals and their impact on placental health: a review. in Environmental Science and Pollution Research. 2022;29:43662-43674. doi:10.1007/s11356-022-20205-1 .
Stojsavljević, Aleksandar, Perović, Milan, Nešić, Andrijana N., Miković, Željko, Manojlović, Dragan D., "Levels of non-essential trace metals and their impact on placental health: a review" in Environmental Science and Pollution Research, 29 (2022):43662-43674, https://doi.org/10.1007/s11356-022-20205-1 . .