Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters
Само за регистроване кориснике
2022
Аутори
Marković, Sanja B.Maciejewska, Natalia
Olszewski, Mateusz
Višnjevac, Aleksandar
Puerta, Adrián
Padrón, José M.
Novaković, Irena T.
Kojić, Snežana
Fernandes, Henrique S.
Sousa, Sérgio F.
Ramotowska, Sandra
Chylewska, Agnieszka
Makowski, Mariusz
Todorović, Tamara
Filipović, Nenad R.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The paradigm of metal toxicity has been challenged suggesting that metal toxicity is not a constant property, yet it depends on many factors like the presence of appropriate ligands. Studies on anticancer activity of cadmium complexes showed that the complexation of various ligands resulted in complexes that showed better activities than approved drugs. In the present study, cadmium complexes with biologically potent thiazolyl/selenazoyl-hydrazone ligands have been prepared, and tested for their activity against different types of tumor cell models. The complexation of ligands with Cd(II) resulted in a synergistic effect. The antiproliferative activity study revealed that all complexes are more active compared to 5-fluorouracil and cisplatin. The mechanism of tumor cell ...growth inhibition reveal that selenium-based compounds induce cell death in T-47D (gland carcinoma) cells through apoptosis via caspase-3/7 activation. Additionally, their pro-apoptotic effect was stronger compared to etoposide and cisplatin. Nuclease activity, detected by gel electrophoresis, may be the possible mechanism of anticancer action of investigated complexes.
Извор:
European Journal of Medicinal Chemistry, 2022, 238, 114449-Издавач:
- Elsevier
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200168 (Универзитет у Београду, Хемијски факултет) (RS-200168)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200116 (Универзитет у Београду, Пољопривредни факултет) (RS-200116)
- This research is financially supported by the Spanish Government (PGC2018-094503-B-C22, MCIU/AEI/FEDER, UE).
- This research is financially supported by the Canary Islands Government (ProID2020010101, ACIISI/FEDER, UE).
- This research is supported by the EU Social Fund (FSE).
- This research is supported by the Canary Islands ACIISI for a predoctoral grant TESIS2020010055.
DOI: 10.1016/j.ejmech.2022.114449
ISSN: 0223-5234
WoS: 00081014990000
Scopus: 2-s2.0-85130369502
URI
https://www.sciencedirect.com/science/article/pii/S0223523422003518http://cherry.chem.bg.ac.rs/handle/123456789/5209
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Marković, Sanja B. AU - Maciejewska, Natalia AU - Olszewski, Mateusz AU - Višnjevac, Aleksandar AU - Puerta, Adrián AU - Padrón, José M. AU - Novaković, Irena T. AU - Kojić, Snežana AU - Fernandes, Henrique S. AU - Sousa, Sérgio F. AU - Ramotowska, Sandra AU - Chylewska, Agnieszka AU - Makowski, Mariusz AU - Todorović, Tamara AU - Filipović, Nenad R. PY - 2022 UR - https://www.sciencedirect.com/science/article/pii/S0223523422003518 UR - http://cherry.chem.bg.ac.rs/handle/123456789/5209 AB - The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The paradigm of metal toxicity has been challenged suggesting that metal toxicity is not a constant property, yet it depends on many factors like the presence of appropriate ligands. Studies on anticancer activity of cadmium complexes showed that the complexation of various ligands resulted in complexes that showed better activities than approved drugs. In the present study, cadmium complexes with biologically potent thiazolyl/selenazoyl-hydrazone ligands have been prepared, and tested for their activity against different types of tumor cell models. The complexation of ligands with Cd(II) resulted in a synergistic effect. The antiproliferative activity study revealed that all complexes are more active compared to 5-fluorouracil and cisplatin. The mechanism of tumor cell growth inhibition reveal that selenium-based compounds induce cell death in T-47D (gland carcinoma) cells through apoptosis via caspase-3/7 activation. Additionally, their pro-apoptotic effect was stronger compared to etoposide and cisplatin. Nuclease activity, detected by gel electrophoresis, may be the possible mechanism of anticancer action of investigated complexes. PB - Elsevier T2 - European Journal of Medicinal Chemistry T1 - Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters VL - 238 SP - 114449 DO - 10.1016/j.ejmech.2022.114449 ER -
@article{ author = "Marković, Sanja B. and Maciejewska, Natalia and Olszewski, Mateusz and Višnjevac, Aleksandar and Puerta, Adrián and Padrón, José M. and Novaković, Irena T. and Kojić, Snežana and Fernandes, Henrique S. and Sousa, Sérgio F. and Ramotowska, Sandra and Chylewska, Agnieszka and Makowski, Mariusz and Todorović, Tamara and Filipović, Nenad R.", year = "2022", abstract = "The biological activity of Cd compounds has been investigated scarce since Cd has been recognized as a human carcinogen. However, the toxicity of cadmium is comparable to the toxicity of noble metals such as Pt and Pd. The paradigm of metal toxicity has been challenged suggesting that metal toxicity is not a constant property, yet it depends on many factors like the presence of appropriate ligands. Studies on anticancer activity of cadmium complexes showed that the complexation of various ligands resulted in complexes that showed better activities than approved drugs. In the present study, cadmium complexes with biologically potent thiazolyl/selenazoyl-hydrazone ligands have been prepared, and tested for their activity against different types of tumor cell models. The complexation of ligands with Cd(II) resulted in a synergistic effect. The antiproliferative activity study revealed that all complexes are more active compared to 5-fluorouracil and cisplatin. The mechanism of tumor cell growth inhibition reveal that selenium-based compounds induce cell death in T-47D (gland carcinoma) cells through apoptosis via caspase-3/7 activation. Additionally, their pro-apoptotic effect was stronger compared to etoposide and cisplatin. Nuclease activity, detected by gel electrophoresis, may be the possible mechanism of anticancer action of investigated complexes.", publisher = "Elsevier", journal = "European Journal of Medicinal Chemistry", title = "Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters", volume = "238", pages = "114449", doi = "10.1016/j.ejmech.2022.114449" }
Marković, S. B., Maciejewska, N., Olszewski, M., Višnjevac, A., Puerta, A., Padrón, J. M., Novaković, I. T., Kojić, S., Fernandes, H. S., Sousa, S. F., Ramotowska, S., Chylewska, A., Makowski, M., Todorović, T.,& Filipović, N. R.. (2022). Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters. in European Journal of Medicinal Chemistry Elsevier., 238, 114449. https://doi.org/10.1016/j.ejmech.2022.114449
Marković SB, Maciejewska N, Olszewski M, Višnjevac A, Puerta A, Padrón JM, Novaković IT, Kojić S, Fernandes HS, Sousa SF, Ramotowska S, Chylewska A, Makowski M, Todorović T, Filipović NR. Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters. in European Journal of Medicinal Chemistry. 2022;238:114449. doi:10.1016/j.ejmech.2022.114449 .
Marković, Sanja B., Maciejewska, Natalia, Olszewski, Mateusz, Višnjevac, Aleksandar, Puerta, Adrián, Padrón, José M., Novaković, Irena T., Kojić, Snežana, Fernandes, Henrique S., Sousa, Sérgio F., Ramotowska, Sandra, Chylewska, Agnieszka, Makowski, Mariusz, Todorović, Tamara, Filipović, Nenad R., "Study of the anticancer potential of Cd complexes of selenazoyl-hydrazones and their sulfur isosters" in European Journal of Medicinal Chemistry, 238 (2022):114449, https://doi.org/10.1016/j.ejmech.2022.114449 . .