Estimation of the hydrophobicity of antimycotic compounds by planar chromatography
Чланак у часопису
МетаподациПриказ свих података о документу
The retention behavior of bifonazole, clotrimazole, fenticonazole, fluconazole, ketoconazole, miconazole, metronidazole, and itraconazole, widely used antimycotic drugs have been determined by TLC by use of the binary mobile phases acetone-n-hexane, methanol-toluene, and methyl ethyl ketone-toluene containing different amounts of organic modifier. Hydrophobicity was established from the linear relationships between the solute R-M values and the concentration of organic modifier. Calculated values of R-M(0) and C-0 were considered for application in QSAR studies of the antimycotics.
Кључне речи:TLC / antimycotic compounds / hydrophobicity / QSAR
Извор:Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 2002, 15, 6, 414-417
- Research Inst Medicinal Plants, Budakalasz