Estimation of the hydrophobicity of antimycotic compounds by planar chromatography
Apstrakt
The retention behavior of bifonazole, clotrimazole, fenticonazole, fluconazole, ketoconazole, miconazole, metronidazole, and itraconazole, widely used antimycotic drugs have been determined by TLC by use of the binary mobile phases acetone-n-hexane, methanol-toluene, and methyl ethyl ketone-toluene containing different amounts of organic modifier. Hydrophobicity was established from the linear relationships between the solute R-M values and the concentration of organic modifier. Calculated values of R-M(0) and C-0 were considered for application in QSAR studies of the antimycotics.
Ključne reči:
TLC / antimycotic compounds / hydrophobicity / QSARIzvor:
Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 2002, 15, 6, 414-417Izdavač:
- Research Inst Medicinal Plants, Budakalasz
DOI: 10.1556/JPC.15.2002.6.4
ISSN: 0933-4173
WoS: 000180914000004
Scopus: 2-s2.0-0036874491
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Aleksic, M AU - Erić, S. AU - Agbaba, Danica G. AU - Odovic, J AU - Milojković-Opsenica, Dušanka AU - Tesic, I PY - 2002 UR - https://cherry.chem.bg.ac.rs/handle/123456789/538 AB - The retention behavior of bifonazole, clotrimazole, fenticonazole, fluconazole, ketoconazole, miconazole, metronidazole, and itraconazole, widely used antimycotic drugs have been determined by TLC by use of the binary mobile phases acetone-n-hexane, methanol-toluene, and methyl ethyl ketone-toluene containing different amounts of organic modifier. Hydrophobicity was established from the linear relationships between the solute R-M values and the concentration of organic modifier. Calculated values of R-M(0) and C-0 were considered for application in QSAR studies of the antimycotics. PB - Research Inst Medicinal Plants, Budakalasz T2 - Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography T1 - Estimation of the hydrophobicity of antimycotic compounds by planar chromatography VL - 15 IS - 6 SP - 414 EP - 417 DO - 10.1556/JPC.15.2002.6.4 ER -
@article{ author = "Aleksic, M and Erić, S. and Agbaba, Danica G. and Odovic, J and Milojković-Opsenica, Dušanka and Tesic, I", year = "2002", abstract = "The retention behavior of bifonazole, clotrimazole, fenticonazole, fluconazole, ketoconazole, miconazole, metronidazole, and itraconazole, widely used antimycotic drugs have been determined by TLC by use of the binary mobile phases acetone-n-hexane, methanol-toluene, and methyl ethyl ketone-toluene containing different amounts of organic modifier. Hydrophobicity was established from the linear relationships between the solute R-M values and the concentration of organic modifier. Calculated values of R-M(0) and C-0 were considered for application in QSAR studies of the antimycotics.", publisher = "Research Inst Medicinal Plants, Budakalasz", journal = "Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography", title = "Estimation of the hydrophobicity of antimycotic compounds by planar chromatography", volume = "15", number = "6", pages = "414-417", doi = "10.1556/JPC.15.2002.6.4" }
Aleksic, M., Erić, S., Agbaba, D. G., Odovic, J., Milojković-Opsenica, D.,& Tesic, I.. (2002). Estimation of the hydrophobicity of antimycotic compounds by planar chromatography. in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography Research Inst Medicinal Plants, Budakalasz., 15(6), 414-417. https://doi.org/10.1556/JPC.15.2002.6.4
Aleksic M, Erić S, Agbaba DG, Odovic J, Milojković-Opsenica D, Tesic I. Estimation of the hydrophobicity of antimycotic compounds by planar chromatography. in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography. 2002;15(6):414-417. doi:10.1556/JPC.15.2002.6.4 .
Aleksic, M, Erić, S., Agbaba, Danica G., Odovic, J, Milojković-Opsenica, Dušanka, Tesic, I, "Estimation of the hydrophobicity of antimycotic compounds by planar chromatography" in Journal of Planar Chromatography: Modern TLC / Thin Layer Chromatography, 15, no. 6 (2002):414-417, https://doi.org/10.1556/JPC.15.2002.6.4 . .