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Hemijske modifikacije β-laktoglobulina hinonima

dc.creatorNovaković, Irena T.
dc.creatorVujčić, Zoran
dc.creatorBožić, Tatjana T.
dc.creatorBozic, N
dc.creatorMilosavic, N
dc.creatorSladić, Dušan
dc.date.accessioned2018-11-22T00:06:07Z
dc.date.available2018-11-22T00:06:07Z
dc.date.issued2003
dc.identifier.issn0352-5139
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/552
dc.description.abstractThe avarone/avarol quinone/hydroquinone couple. as well as their derivatives show considerable antitumor activity. In this work, covalent modifications of beta-lactogglobulin. isolated from cow milk by avarone, its model compound 2-tert-butyl-1,4-benzoquinone. and several of their alkylthio derivatives were studied. The techniques applied for as-saying the modifications were: UV/VIS spectrophotometry, SDS PAGE and isoelectrofocusing. The results of the SDS PAGE suggest that polymerisation of the protein occurs. The shift of the pI of the protein upon modification toward lower values indicates that lysine amino groups are the principal site of die reaction of beta-lactoglobulin with the quinones.en
dc.description.abstractHinonsko/hidrohinonski par avaron/avarol i njihovi derivati pokazuju značajnu antitumorsku aktivnost. U ovom radu proučavane su kovalentne modifikacije β-laktoglobulina, izolovanog iz kravljeg mleka, avaronom, njegovim model-jedinjenjem 2-tert-butil-1,4-benzohinonom i njihovim alkiltio-derivatima. Za ispitivanje modifikacija korišćene su UV/VIS spektrofotometrija, SDS PAGE i izoelektrofokusiranje. Rezultat SDS PAGE ukazuje da se protein polimerizuje. Pomeranje pI vrednosti proteina nakon modifikacije ka nižim vrednostima pokazuje da su amino grupe lizina glavna mesta reakcije β-laktoglobulina sa hinonima.sr
dc.publisherSerbian Chemical Soc, Belgrade
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectavaroneen
dc.subjectquinoneen
dc.subjectquinoneen
dc.subjectβ-lactoglobulinen
dc.subjectbeta-lactoglobulinen
dc.subjectcovalent modificationen
dc.subjectcovalent modificationen
dc.titleChemical modification of beta-lactoglobulin by quinonesen
dc.titleHemijske modifikacije β-laktoglobulina hinonimasr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractНоваковиц, И; Вујчић, Зоран; Бозиц, Т; Сладић, Душан; Бозиц, Н; Милосавиц, Н; Хемијске модификације β-лактоглобулина хинонима; Хемијске модификације β-лактоглобулина хинонима;
dc.citation.volume68
dc.citation.issue4-5
dc.citation.spage243
dc.citation.epage248
dc.identifier.wos000183423800002
dc.identifier.doi10.2298/JSC0305243N
dc.citation.other68(4-5): 243-248
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-0037498109
dc.identifier.rcubKon_1526


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